Abstract: Objective: To explore the stress distribution of customized titanium mesh for large bone defect under the loading of 100 N by finite element analysis so as to provide biomechanical guidance for the design of personalized titanium mesh. Methods: The three-dimensional reconstruction of the mandible was reconstructed based on the CBCT scanning data and the individualized titanium mesh with different thicknesses were designed. Then, three-dimensional finite element modeling and finite element mechanical analysis were carried out. Results: Under the loading of 100 N, the stress distribution of titanium mesh was uniform and without stress concentration. With the increase of thickness, the maximum Von Mises stresses of titanium mesh were in a downward trend, the stress of titanium screw was not related to the thickness of titanium mesh. Conclusion: Titanium mesh with 0.3 mm thickness can withstand less power, which may not meet the clinical needs for larger bone tissue defects, especially in posterior teeth. The stress values of the titanium mesh with thickness of 0.4 mm and 0.5 mm are all within the safe equivalent stress range of titanium mesh. They have enough strength and are suitable for clinical needs. Considering that the titanium mesh may result in mucosal irritation that leads to exposure of the membrane, the titanium mesh with a thickness of 0.4 mm is more appropriate for clinical need.

Key words: Three dimensional finite element, Three dimensional reconstruction, Customized titanium mesh