Effect of Static Magnetic Field on Mandibular Fracture Healing in Rats

doi:10.13701/j.cnki.kqyxyj.2020.06.011

Abstract

Abstract: Objective: To study the effect of static magnetic field on the healing process of mandibular fracture in rats. Methods: 60 SD rats were randomly divided into three groups: fracture operation (group C), fracture operation + fracture covered ceramic (group S), fracture surgery + neodymium magnet with 0.1T covering magnetic field at fracture site (Group L). The body weight, diet, and drinking water of SD rats were investigated every week after operation, and the samples were taken after 2, 4, 6, and 8 weeks. Bone fracture healing was observed by X-ray examination. Expression of BMP-2 and IL-1 in serum was detected by ELISA. Serum calcium was determined by arsenazo Ⅲ method. Fracture area was observed by HE staining. Osteogenesis related genes BMP-2, OPG, and OCN were immunohistochemical detected. Results: X-ray results showed that group L had the best effect of fracture healing, the expressions of BMP-2, IL-1, and calcium in group L were higher than those in group S and C. HE staining showed that the number of new bone trabeculae in group L was significantly more than that in group C and group S. Immunohistochemical results showed that magnetostatic field could promote the synthesis and secretion of BMP-2, OPG, and OCN. Conclusion: Static magnetic field can effectively promote fracture healing.

Key words: static magnetic field, fracture healing, osteogenic factor

LIU Yang, LI Shanchang, WANG Changzhen, ZHOU Hongmei, DONG Guofu, ZHAO Xuelong, LIU Qi. Effect of Static Magnetic Field on Mandibular Fracture Healing in Rats[J]. Journal of Oral Science Research, 2020, 36(6): 548-553.

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