Comparative Analysis on Formation Mechanism of Oral Microbial Diversity Between Smokers and Non-smokers

doi:10.13701/j.cnki.kqyxyj.2022.10.018

Abstract

Abstract: Objective: To explore the influence mechanism of tobacco on the formation and succession of oral microbial diversity. Methods: The specific growth rate, lipid content, and population number of Streptococcus, Prevotella, Haemophilus, Rothia, and Veillonella were investigated in the oral cavity of 20 smokers and 20 non-smokers for 4 months. Results: The intracellular lipid content of non-smoker oral microorganisms increased significantly, but the specific growth rate varied. Formation and maintain non-smoker oral microbial diversity included two basic dynamic mechanism, one was the substrate decomposition product negative feedback regulation of population, and the second was the delay response of microorganisms in oral environment. On the contrary, in smokers, the diversity of oral flora decreased and had a trend of disorder. Conclusion: Smoking has a negative effect on the diversity of oral microflora, which is difficult to form a stable population diversity. The number of each species in non-smokers oral microbial community showed asynchronous convergence fluctuations, which greatly weakened the interspecific competition within the oral microbiome and formed and maintained a higher species diversity.

Key words: microbial diversity, feedback regulation, time-delay response, cellular automata model, computer simulation

KANG Jizhe, WANG Wei, YE Junjie, YANG Yang, DONG Chen. Comparative Analysis on Formation Mechanism of Oral Microbial Diversity Between Smokers and Non-smokers[J]. Journal of Oral Science Research, 2022, 38(10): 986-990.

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