A Survey on Oral Health Status in Children with Primary Nephrotic Syndrome

doi:10.13701/j.cnki.kqyxyj.2022.12.017

Abstract

Abstract: Objective: To assess the oral health status of children with primary nephrotic syndrome and to explore the oral related risk factors. Methods: One hundred and twenty children aged 3-6 years with primary nephrotic syndrome were recruited as the experimental group and 120 healthy children as the control group for oral examination. Results: The incidence of caries, mean dmft, median Cariostat scores, median PLI, median GI, incidence of apical fistula, incidence of enamel hypoplasia, and median sIgA levels in the experimental group and the control group were 85.8% and 74.2% (P<0.05), 6.69±4.71 and 5.16±4.69 (P<0.05), 2.0 (1.0) and 1.75 (1.5) (P<0.05), 1.6 (0.9) and 1.35 (1.3) (P>0.05), 1.00 (0.28) and 0.65 (0.7) (P<0.05), 10.8% and 3.33% (P<0.05), 5.80% and 3.33% (P>0.05), and 4.65 (4.61) μg/mL and 1.08 (0.99) μg/mL (P<0.05), respectively. Caries OR=2.110, 95%CI=1.095-4.067, apical fistula OR=3.523, 95%CI=1.114-11.139. Conclusion: 3-6 years PNS children have more serious caries than healthy children at the onset of the disease, with higher risk of caries and more severe gingival inflammation. Caries and chronic periapical periodontitis may be corelated with the occurrence of PNS.

Key words: nephrotic syndrome, oral health, risk factors

WANG Mingmin, KONG Nannan, GUO Xueyan, LI Yaqi. A Survey on Oral Health Status in Children with Primary Nephrotic Syndrome[J]. Journal of Oral Science Research, 2022, 38(12): 1187-1191.

References

[1] 杨帆,蒋小云.儿童激素敏感、复发/依赖肾病综合征诊治循证指南(2016)解读[J].中华儿科杂志,2017,55(10):729-734.
[2] Noone DG, Iijima K, Parekh R. Idiopathic nephrotic syndrome in children[J]. Lancet, 2018, 392(10141): 61-74.
[3] 王兴.第四次全国口腔健康流行病学调查报告[M].北京:人民卫生出版社,2018:12-25.
[4] 葛立宏.儿童口腔医学.第5版[M].北京:人民卫生出版社,2020:158.
[5] Organization WH. Oral health surveys: basic methods[M]. 5th ed. Geneve: World Health Organization, 2013.
[6] Chawda JG, Chaduvula N, Patel HR, et al. Salivary SIgA and dental caries activity[J]. Indian Pediatr, 2011, 48(9): 719-721.
[7] Pal S, Mitra M, Mishra J, et al. Correlation of total salivary secretory immunoglobulin A (SIgA) and mutans specific SIgA in children having different caries status[J]. J Indian Soc Pedod Prev Dent, 2013, 31(4):270-274.
[8] Albers R, Antoine JM, Bourdet-Sicard R, et al. Markers to measure immunomodulation in human nutrition intervention studies[J]. Br J Nutr, 2005, 94(3): 452-481.
[9] Son TM, Huong NT, Hanh TTM, et al. Dental caries status and relevant factors in children with primary nephrotic syndrome in national children hospital, vietnam[J]. Int J Oral Craniofac Sci, 2018, 4(1): 1-4.
[10] Piróg A, Michałek-Pasternak E, Mizerska-Wasiak M, et al. The incidence and intensity of dental caries in children with nephritic syndrome[J]. Nowa Stomatologia, 2012.
[11] Luong HM, Nguyen TT, Tran HT, et al. Oro-dental health and primary nephrotic syndrome among vietnamese children[J]. Children (Basel), 2021, 8(6): 494.
[12] Güzel KGU, Yilmaz D, Abacigil F, et al. Oral aspects in children with nephrotic syndrome[J]. Turkiye Klinikleri. Dishekimligi Bilimleri Dergisi, 2018, 24(3): 183-189.
[13] Babu NSV, Jana S. Assessment of oral health status in children suffering from nephrotic syndrome[J]. Int J Sci Study, 2014, 2(2): 19-23.
[14] Kaczmarek U, Wrzyszcz-Kowalczyk A, Jankowska K, et al. Oral health conditions in children with idiopathic nephrotic syndrome: a cross-sectional study[J]. BMC Oral Health, 2020, 20(1): 213.
[15] Subramaniam P, Gupta M, Mehta A. Oral health status in children with renal disorders[J]. J Clin Pediatr Dent, 2012, 37(1):89-93.
[16] Nunn JH, Sharp J, Lambert HJ, et al. Oral health in children with renal disease[J]. Pediatr Nephrol, 2000, 14(10-11):997-1001.
[17] Rostoker G, Terzidis H, Petit-Phar M, et al. Secretory IgA are elevated in both saliva and serum of patients with various types of primary glomerulonephritis[J]. Clin Exp Immunol, 1992, 90(2): 305-311.