Abstract: Objective: To explore the effect of co-doping with TiO₂ nanoparticles and sisal cellulose nanocrystals (CNCs) on the physical and antibacterial properties of a conventional glass-ionomer cement (GIC). Methods: Test samples were divided into three groups: 2wt.% titanium dioxide group (T), 2wt.% titanium dioxide + 0.4wt.% CNCs co-doped group (C), and unmodified cement control group (CG). The samples were subjected to mechanical tests to evaluate the compressive strength and wear resistance. Antimicrobial activity was evaluated against candida albicans. Results: Compared with the control group, the co-doped group demonstrated an increased compressive strength of 21.8%(P<0.001), the volume wear rate was reduced to 35.9% (P<0.001). The antibacterial effect against candida albicans was increased to 92.3%(P<0.001). Scanning electron microscopy showed a significant reduction of cracks in group C. Conclusion: The co-doping of CNCs and TiO₂ nanoparticles significantly improve the compressive properties, abrasion resistance, and antibacterial effect of GIC.

Key words: Glass-ionomercement, Nanoparticles, Mechanics, Antimicrobial