Expression and Clinical Significance of EGFR, MTDH, and ERCC1 in Special Subtypes of Oral Squamous Carcinoma

doi:10.13701/j.cnki.kqyxyj.2018.06.012

Abstract

Abstract: Objective: To explore the expression of EGFR, MTDH, and ERCC1 in special subtypes of oral squamous cell carcinoma. Methods: Immunohistochemistry polymer was applied to detect special subtypes of oral squamous cell carcinoma. Results: The expression of EGFR in oral adenosquamous carcinoma was higher than that of basaloid squamous cell carcinoma, papillary squamous cell carcinoma, and spindle cell carcinoma, and the expression in verrucous carcinoma was the weakest(P＜0.05). The expressions of MTDH and ERCC1 in oral adenosquamous carcinoma were higher than those of basaloid squamous cell carcinoma, papillary squamous cell carcinoma, and verrucous carcinoma, and the expressions in spindle cell carcinoma was the weakest(P＜0.05). The metastasis rate of lymph nodes in oral adenosquamous carcinoma was higher than that of basaloid squamous cell carcinoma, and the rates in papillary squamous cell carcinoma, spindle cell carcinoma, and verrucous carcinoma were weaker(P＜0.05). Conclusion: The levels of EGFR, MTDH, and ERCC1 can be used as important biomarkers for evaluation,which may provide the basis for the treatments of special subtypes of oral squamous cell carcinoma.

Key words: Oral squamous carcinoma, Special subtypes, EGFR, MTDH, ERCC1

CHEN Wei-hua, PEI Jing, JIA Yun-xiang. Expression and Clinical Significance of EGFR, MTDH, and ERCC1 in Special Subtypes of Oral Squamous Carcinoma[J]. Journal of Oral Science Research, 2018, 34(6): 623-626.

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