Correlation between Periodontitis and Hyperlipidemia

doi:10.13701/j.cnki.kqyxyj.2018.11.011

Abstract

Abstract: Objective: To explore the relationship between periodontitis and hyperlipidemia. Method: The serum from severe chronic periodontitis patients and healthy volunteers was gathered and tested the concentrations of cholesterol, triglycerides, high density lipoprotein, and low density lipoprotein. The influence of periodontal basic treatment for the blood lipid levels was researched. In addition, the rat experimental hyperlipoidemia and periodontitis models were established by high fat diet and periodontal ligation, whose blood lipid levels and expression of CD3, CD4, and CD8 in the periodontal tissue cells were detected by flow cytometry. Result: The blood lipid levels of severe chronic periodontitis patients were similar to that of health volunteers. The levels of cholesterol, triglycerides, high density lipoprotein, and low density lipoprotein of patients with severe periodontitis and hyperlipidemia were not significantly changed after periodontal basic treatment for 3 months. The results of this clinical test were further validated by animal experiments. The expression proportion of CD3⁺, CD4⁺, and CD8⁺T cells in the simple hyperlipidemia group were higher than that of blank control group. Conclusion: Periodontitis does not cause hyperlipidemia, but hyperlipidemia can promote periodontitis.

Key words: Periodontitis, Hyperlipidemia, Animal models

HOU Da-wei, GUO Jian-qing, YUE Hai-quan, GOU Xue-li, LIU Rui-min. Correlation between Periodontitis and Hyperlipidemia[J]. Journal of Oral Science Research, 2018, 34(11): 1192-1195.

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