Expression of JAK2 and STAT3 in Chronic Periapical Periodontitis

doi:10.13701/j.cnki.kqyxyj.2019.01.020

Journal of Oral Science Research ›› 2019, Vol. 35 ›› Issue (1): 84-88.DOI: 10.13701/j.cnki.kqyxyj.2019.01.020

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Expression of JAK2 and STAT3 in Chronic Periapical Periodontitis

ZHANG Chen^1,2, LIU Jun³, ZHAO Han⁴, LIU Ling-shuang^1*

1. Department of Stomatology, Affiliated Hospital, Qingdao University, Qingdao 266000, China;
2. Qingdao University, Qingdao 266071, China;
3. Department of Orthodontics, Affiliated Hospital of Qingdao University, Qingdao 266003, China;
4. Department of Pathology, Affiliated Hospital of Qingdao University, Qingdao, 266555, China

Received:2018-06-25 Online:2019-01-18 Published:2019-01-28

Abstract

Abstract: Objective: To detect the expression of JAK2/STAT3 signal transduction pathway in chronic apical periodontitis in human and speculate its role in chronic periapical diseases. Methods: Twenty healthy periodontal membranes, 20 periapical cysts, and 20 periapical granuloma specimens were stained by HE. Immunohistochemistry was used to detect the expression of JAK2, p-JAK2, STAT3, and p-STAT3 in different groups. Results: JAK2, p-JAK2, STAT3, and p-STAT3 were slightly expressed in normal tissues, and increased in periapical cysts and granuloma. The differences were statistically significant (P<0.05). The difference between JAK2 and p-JAK2 was statistically significant (P<0.05). There was no significant difference in STAT3 and p-STAT3 between periapical cyst group and periapical granuloma group (P>0.05). Tere was a correlation between JAK2 and STAT3 and p-JAK2 and p-STAT3. Conclusion: The expressions of JAK2, p-JAK2, STAT3, and p-STAT3 were increased in chronic periapical diseases. We speculate that JAK2/STAT3 signaling pathway is involved in the inflammatory process of periapical perioditis and may play an important role in its development.

Key words: JAK2, Periapical granuloma, Periapical cyst

ZHANG Chen, LIU Jun, ZHAO Han, LIU Ling-shuang. Expression of JAK2 and STAT3 in Chronic Periapical Periodontitis[J]. Journal of Oral Science Research, 2019, 35(1): 84-88.

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Expression of JAK2 and STAT3 in Chronic Periapical Periodontitis

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