Expression and Clinical Significance of CD147 and CypA in Periapical Granulomas and Radicular Cysts.

doi:10.13701/j.cnki.kqyxyj.2016.07.015

Abstract

Abstract: Objective: To investigate the expression of extracellular matrix metalloproteinase inducer (CD147) and Cyclophilin A (CypA) in periapical granulomas (PGs) and radicular cysts (RCs). The interaction of CD147 with CypA and their roles in periapical pathogenesis were also speculated. Methods: Thirty PGs and thirty-five RCs were collected after periapical surgery as the experimental samples. Eight alveolar bone samples were obtained from extraction of impacted third molars or alveoloplasty as the control samples. The lesion size was recorded by CBCT. The protein expression of CD147 and CypA was observed by immunohistochemical analysis for all samples. Statistical analysis was performed to evaluate the differences of expression of CD147 and CypA. Results: The expression of CD147 and CypA in RCs were higher than in PGs (P<0.05). Positive correlations between CD147 and CypA protein levels were observed in PGs and RCs (P<0.05), respectively. Furthermore, the expression of CD147 and CypA was positively correlated with the lesion size (P<0.05). Conclusion: These findings demonstrated that CD147 and CypA might be involved in the inflammatory response, bone resorption of periapical lesions tissues. The CD147-CypA interactions may play a synergistic role in the development and progression of periapical lesion.

Key words: CD147, Cyclophilin A , Radicular cyst , Periapical granuloma

CLC Number:

R781.34

HU Shu-li,WANG Yan-qing,DONG Yan,ZHANG Hong-yan.. Expression and Clinical Significance of CD147 and CypA in Periapical Granulomas and Radicular Cysts.[J]. Journal of Oral Science Research, 2016, 32(7): 723-728.

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