Expression and Significance of CD147, MMP-9, and VEGF in Salivary Gland Tumors

doi:10.13701/j.cnki.kqyxyj.2018.12.009

Abstract

Abstract: Objective: To investigate the expression and significance of CD147, MMP-9, and VEGF in salivary gland tumor tissues.Methods: From February 2010 to November 2017, 120 paraffin samples were collected for examination after salivary gland surgery, including 80 cases of salivary gland malignant tumor, 20 cases of salivary gland benign tumor, and 20 cases of normal salivary gland tissue.The normal salivary gland tissue was used as a control group.The expression of CD147, MMP-9 and VEGF were detected by SP immunohistochemical method.Results: Protein positive expression rates for CD147, MMP-9, and VEGF: salivary gland malignant tumor tissue > salivary gland benign tumor > normal salivary gland tissue (P＜0.05).The expressions of CD147, MMP-9, and VEGF were related to metastasis of cancer cells, nerve infiltration, and cervical lymph node metastasis (P＜0.05), but not related to patient's age, pathological type, and original site (P>0.05).The expression of CD147, MMP-9, and VEGF in malignant tumor of salivary gland showed significant correlation (P＜0.001).Conclusion: The synergistic of CD147, MMP-9, and VEGF may play an important role in the occurrence, development, invasion, and metastasis of salivary gland tumors.

Key words: Salivary gland tumors, CD147, MMP-9, VEGF

LI Kuang-zheng,JIANG Yi-xia,FAN Xiao-sheng, REN Qian, CAO Fang-yun. Expression and Significance of CD147, MMP-9, and VEGF in Salivary Gland Tumors[J]. Journal of Oral Science Research, 2018, 34(12): 1297-1301.

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