Experimental Study on Influence of Aging Factors on Orthodontic Tooth Movement.

doi:10.13701/j.cnki.kqyxyj.2017.02.002

Abstract

Abstract: Objective: To explore the effects of aging factors on the expression of HIF-1α and VEGF in the periodontal tissues during orthodontic tooth movement in rats. Methods: Orthodontic tooth movement animal models with different ages were established. The expressions of HIF-1α and VEGF in the periodontal tissues were detected by immunohistochemistry method at day 1, 3, 7, 14 and 28 after orthodontic force application. Results: The expression of HIF-1α in the young group was significantly higher than that in the adult group at day 1 and 3. The expression of VEGF was higher than that in the adult group at day 1, 3, 7 and 14. Conclusion: Aging factors can decrease the reaction of the periodontal tissue, and slow down the rate of hypoxia regulation. Finally, the alveolar bone remodeling and the speed of tooth movement would decrease. VEGF plays an important role in the periodontal tissue remodeling. But the expression of VEGF increases slowly in the adult group. The speed of alveolar bone reconstruction reduced, as well as the speed of tooth movement.

Key words: Tooth movement , Periodontal tissue, Aging , HIF-1α , VEGF

CLC Number:

R783.5

ZHOU Xin-wen, QU Sheng-ai, XU Hui. Experimental Study on Influence of Aging Factors on Orthodontic Tooth Movement.[J]. Journal of Oral Science Research, 2017, 33(2): 123-126.

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