Abstract: Objective: To study the clinical and imaging features, treatment, and prognostic factors of Madelung's disease. Methods: The location, clinical appearance, laboratory findings, imaging features, treatment, and prognosis of Madelung's disease were retrospectively analyzed. Results: Male-to-female ratio of Madelung's disease was 14:1, with an average age of (52.1±6.7)years. 84.6% of the patients had a long-term drinking history, and 80% of them occurred in anterior cervical region and neck region. 69.2% of the patients had abnormal liver function, mainly with elevated gamma-glutamyltransferase, of which 88.8% had a history of drinking. The main manifestation was the diffuse symmetry distribution of the tumor, painless and slow growth, and the boundary with the surrounding tissue was unclear. CT and MR showed symmetrical accumulation of subcutaneous fat without envelope, unclear boundaries, linear or reticular fibrous septum, compression, displacement, atrophy and deformation of adjacent muscles and glands. 10 patients had different degrees of cervical disc herniation and cervical degenerative changes. Fourteen patients underwent open surgical resection, 2 patients had postoperative complications. Four patients had recurrence after operation. Conclusion: Madelung's disease is predominant in middle-aged males. Heavy drinking is one of the inducing factors of Madelung's disease. The lesions mainly occur in the neck and scapula. Most patients with liver dysfunction are mainly caused by heavy drinking. CT and MRI play an important role in the diagnosis and treatment of Madelung's disease. Most patients have cervical spondylosis. Open surgical resection can significantly improve the patient's morphology and function. High recurrence rate of alcohol consumption occurs in patients with Madelung's disease after operation.

Key words: Madelung's disease, clinical features, imaging features, treatment methods, prognostic factors