Effect of Quercetin on Periodontal Tissues and Serum AGEs Levels in Rats with Diabetic Periodontitis

doi:10.13701/j.cnki.kqyxyj.2021.07.011

Abstract

Abstract: Objective: To observe the periodontal tissue morphology, alveolar bone resorption, blood glucose, and the differences in the content of serum advanced glycation end products (AGEs) through quercetin treatment in type Ⅱ diabetic periodontitis rats, and explore the protective effect of quercetin on the periodontal tissue of diabetic periodontitis rats. Methods: Forty male SD rats were randomly divided into 4 groups: blank control group (N group), periodontitis control group (P group), diabetic periodontitis non-treatment group (DP group), and diabetic periodontitis quercetin treatment group (DP+ Q group). The N group was fed normally, the P group was established a periodontitis model, and the DP group and DP+Q group were established diabetic periodontitis models, with 10 rats in each group. After successful modeling, the DP+Q group was gavaged with quercetin liposomes, and the DP group was gavaged with blank liposomes. After 6 weeks, blood glucose was measured, serum AGEs content was measured by ELISA method, periodontal tissue section of maxilla was taken to observe the pathological changes of periodontal tissue, and the amount of alveolar bone absorption was measured. Results: The amount of alveolar bone resorption and periodontal inflammation in P group were higher than those in N group (P<0.05). The blood glucose level, serum AGEs content, periodontal tissue inflammation, and alveolar bone absorption in the DP group were higher than those in the N group and P group (P<0.05). Compared with the DP group, the rats in the DP+Q group had lower blood glucose levels, lower serum AGEs content, lower alveolar bone absorption, and significantly lighter periodontal tissue inflammation (P<0.05). Conclusion: Quercetin has a protective effect on the periodontal tissues of diabetic periodontitis rats, and the mechanism is related to the lowering of blood glucose and the content of serum AGEs.

Key words: diabetes, periodontitis, quercetin, advanced glycation end products, rats

GUO Xiaoyu, LI Shujuan, LIANG Xiangyang, QI Yali, LI Ya, YANG Dongru. Effect of Quercetin on Periodontal Tissues and Serum AGEs Levels in Rats with Diabetic Periodontitis[J]. Journal of Oral Science Research, 2021, 37(7): 628-631.

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