pIgR/sIgA and Oral Diseases

doi:10.13701/j.cnki.kqyxyj.2021.08.001

Abstract

Abstract: The mucosal immune system is the first line of defense against all kinds of antigens. The oral cavity is protected by the mucosal immune system. The sIgA in saliva is essential to protect the transmission of oral mucosal pathogens and maintain the homeostasis of oral mucosal surface. As a special transporter protein, polymer immunoglobulin receptor (pIgR) is a key participant in the formation and secretion of sIgA. In oral mucosal immunity, pIgR plays an important role in the defense of oral bacteria. Reducing the expression of pIgR in submandibular gland will inhibit the secretion of sIgA into saliva, and lower levels of sIgA in saliva make it easier for bacteria to enter the epithelial surface, leading to a variety of diseases. This article reviews the function of pIgR/sIgA in oral diseases and its immune regulation mechanism, in order to provide more research ideas for the study of pIgR/sIgA in oral microenvironment.

Key words: polymer immunoglobulin receptor, oral diseases, secretory immunoglobulin, antibody transport

LIU Jianguo, ZHAO Yujie. pIgR/sIgA and Oral Diseases[J]. Journal of Oral Science Research, 2021, 37(8): 677-681.

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