Endoplasmic Reticulum Stress and Autophagy in the Study of Oral Diseases.

doi:10.13701/j.cnki.kqyxyj.2018.05.001

Abstract

Abstract: Endoplasmic reticulum (ER) is a multifauncional oranelle responsible for intracellular protein synthesis and calcium storage, involved in various physiological activities. Mutiple external stimuli such as hypoxia stress, toxic substances and so on will lead to the endoplasmic reticulum dysfunction, resulting in unfolded and/or misfolded proteins, calcium homeostasis imbalance, cells damage and physiological function disorder, which will trigger many relative diseases. Autophagy is a cytoprotective mechanism, removing intracellular damaged organelles and unfolded/misfolded proteins, which can relief endoplasmic reticulum stress, restore cell homeostasis and maintain or improve cell viability by providing new marerials and energy. Recent sudies have shown that the interaction between endoplasmic reticulum stress and autophagy may plays a critical role in the development of multiple diseases. This review summarizes the roles of endoplasmic reticulum stress and autophagy in oral diseases.

Key words: Endoplasmic reticulum stress, Autophagy, Oral diseases

LIU Jian-guo, JING Pei. Endoplasmic Reticulum Stress and Autophagy in the Study of Oral Diseases.[J]. Journal of Oral Science Research, 2018, 34(5): 461-466.

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