Role of Nuclear Factor I-C in Tooth Root Development

doi:10.13701/j.cnki.kqyxyj.2021.08.004

Abstract

Abstract: Tooth root development is a complex process, which is jointly controlled by epithelium and mesenchyme and involves the interaction of multiple molecules. The study found that nuclear transcription factor I-C (NFIC) is one of the main molecules that regulate tooth root development. NFIC is involved in the formation of root dentin and root growth through interaction with various molecules including transforming growth factor β (TGF β), KrÜppel-like factor 4 (KLF4), osterix (OSX), hedgehog (HH), AFF4, and trace element zinc. This article will review the role of NFIC in tooth root formation and the molecules related to NFIC.

Key words: NFIC, tooth root development, odontoblast, molecular signal

LIU Xin, XIE Xiaohua. Role of Nuclear Factor I-C in Tooth Root Development[J]. Journal of Oral Science Research, 2021, 37(8): 689-692.

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