Efficacy of Probiotic Aloe Vera Fermentation Gel in Treatment of Recurrent Aphthous Ulcer and Its Effect on Oral Microbiome

doi:10.13701/j.cnki.kqyxyj.2022.01.018

Journal of Oral Science Research ›› 2022, Vol. 38 ›› Issue (1): 85-89.DOI: 10.13701/j.cnki.kqyxyj.2022.01.018

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Efficacy of Probiotic Aloe Vera Fermentation Gel in Treatment of Recurrent Aphthous Ulcer and Its Effect on Oral Microbiome

HU Xiaojing¹, LIN Lu¹, HUANG Zhen², ZHANG Tingting¹, LIU Qing³, SHI Yan^4*

1. Department of Oral Medicine, The Affiliated Stomatological Hospital of Nanchang University, The Key Laboratory of Oral Biomedicine of Jiangxi Province, Jiangxi Province Clinical Research Center for Oral Diseases, Nanchang 330006, China;
2. Department of Orthodontics, The Affiliated Stomatological Hospital of Nanchang University, The Key Laboratory of Oral Biomedicine of Jiangxi Province, Jiangxi Province Clinical Research Center for Oral Diseases, Nanchang 330006, China;
3. School of Stomatology, Nanchang University, The Key Laboratory of Oral Biomedicine of Jiangxi Province, Jiangxi Province Clinical Research Center for Oral Diseases, Nanchang 330006, China;
4. Department of Conservative Dentistry and Endodontics, The Affiliated Stomatological Hospital of Nanchang University, The Key Laboratory of Oral Biomedicine of Jiangxi Province, Jiangxi Province Clinical Research Center for Oral Diseases, Nanchang 330006, China

Received:2021-08-16 Online:2022-01-28 Published:2022-01-21

Abstract

Abstract: Objective: To evaluate the clinical efficacy and oral microbiome composition of patients with recurrent aphthous ulcer treated with probiotic fermentation gel. Methods: A randomized double-blind design was designed to compare the days of ulcer healing between the experimental group and the control group. 35 RAU patients were selected and randomly divided into experimental group and control group. Probiotic aloe fermentation gel was applied locally in experimental group and chitosan gel was applied locally in control group. Saliva of RAU patient was collected before using medicine as PC group. The probiotics group (AA) and the control group (AC) were randomly divided into two groups. Saliva of the two groups was collected after treatment. Saliva from 10 healthy persons was used as negative control (NC group). The clinical treatment effect and oral microbiome composition were evaluated. Results: Probiotic fermentation gel had better wound healing effect (P<0.05). At phylum level: the relative abundance of Actinomycetes increased in the PC group, but decreased in the AA group. At genus level: the relative abundance of Haemophilus and Neisseria decreased, but the relative abundance of Actinomycetes, Granulococcus, and Streptococcus Gastric increased in the PC grou; and the relative abundance was normal in the AA group. Conclusion: Probiotic fermentation can accelerate ulcer healing and normalized microbiota disorders of RAU.

Key words: recurrent aphthous ulcer, oral microbiota, oral microbiome composition, probiotics

HU Xiaojing, LIN Lu, HUANG Zhen, ZHANG Tingting, LIU Qing, SHI Yan. Efficacy of Probiotic Aloe Vera Fermentation Gel in Treatment of Recurrent Aphthous Ulcer and Its Effect on Oral Microbiome[J]. Journal of Oral Science Research, 2022, 38(1): 85-89.

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Efficacy of Probiotic Aloe Vera Fermentation Gel in Treatment of Recurrent Aphthous Ulcer and Its Effect on Oral Microbiome

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