Abstract: Objective: To explore the effect and safety of dental implant treatment on the kidney transplantation patients. Methods: Six patients who had kidney transplantation for 2 years were selected. Fifteen dental implants were inserted. The wound heal, hepatorenal function, abbreviation for blood and urine routine, concentration of FK506, implant osseointegration, and bone resorption were recorded at every review time. Results: All implants obtained osseointegration in the 3-10 years' follow-up. There were no changes in hepatorenal function, abbreviation for blood, and urine routine in the 3 years' follow-up. Urine protein positive and hematuresis were found in 2 patients after 5 years. One implant lost osseointegration after 8 years. The bone resorption around implants after 1, 5, and 8 years were (0.81±0.19) mm, (1.02±0.29) mm, and (1.54±0.37) mm. The PD was (1.63±0.77) mm, (1.92±0.59) mm, and (2.32±0.46) mm. There was no significant difference between each follow-up. Conclusion: An ideal function of dental implant restoration may be acquired for patients with kidney transplantation, provided that preoperative and postoperative infection was prevented and the indication was strictly controlled.

Key words: kidney transplantation, dental implant, immunosuppressant, safety, effect