Abstract: Objective: To explore a safe and effective treatment for acute pulpitis in early pregnancy. Methods: Twenty-nine patients (29 teeth) with acute pulpitis diagnosed in the early pregnancy were treated with oral hygiene instruction before operation to relieve their anxiety. The access and coronal cavity preparation was performed under Single Tooth Anesthesia System. ApexCal paste was placed with temporary glass ionomer sealers after cleaning and shaping the root canal system. Root canal obturation was completed 2-3 months after delivery. The VAS pain rating scale before and 48 hours after the operation, the condition of teeth during the drug sealing period, and the pregnancy outcome and newborn condition (Apgar rating scale) were recorded. Follow-up was performed 12 months after root canal therapy. Results: There was a significant difference in VAS pain scores before and 48 hours after operation (P<0.001). After root canal preparation, 28 cases had effective pain relief and safely passed the pregnancy period. The effective rate was 96.6%. After 12 months of reexamination, 27 cases were finally treated successfully, with a success rate of 93.1%. All patients did not have adverse pregnancy outcomes, such as abortion, and Apgar scoring scale assessed normal newborns. Conclusion: The patients with acute pulpitis in early pregnancy can delay the completion of root canal obturation with painless, aseptic, and minimally invasive operation on the premise of eliminating anxiety, which is safe and effective.

Key words: early pregnancy, acute pulpitis, root canal therapy, security