Vascularization-related Pathogenesis and Treatment Progress of Osteonecrosis of the Jaw

doi:10.13701/j.cnki.kqyxyj.2025.02.001

Abstract

Abstract: Osteonecrosis of the jaw is a common oral disease involving the jaw after tooth extraction, injury, and radiotherapy, including osteoradionecrosis and medication-related osteonecrosis of the jaw. Its main clinical manifestations are bone exposure, pain, infection, and pathological fracture. The pathogenesis of osteonecrosis of the jaw involves various hypotheses, among which vascular abnormalities are one of the essential mechanisms. Radiation promotes thrombosis by damaging endothelial cells and creating a hypercoagulable state of blood, which becomes a key link in the initiation of osteoradionecrosis of the jaw. Angiogenesis inhibition plays an important role in the development of medication-related osteonecrosis of jaw and is associated with a variety of cells such as macrophages, endothelial cells, preosteoclasts, and their secreted cytokines. Promoting angiogenesis can alleviate or treat osteonecrosis of the jaw. Regulation of vascular function is expected to be a therapeutic option for osteonecrosis of the jaw. This article reviews the vascular-related pathogenesis of osteonecrosis of the jaw and explores potential applications for therapeutic strategies.

Key words: osteoradionecrosis of the jaw, thrombosis, medication-related osteonecrosis of the jaw, angiogenesis inhibition, therapeutic strategies

SHI Yixin, CHEN Junyu. Vascularization-related Pathogenesis and Treatment Progress of Osteonecrosis of the Jaw[J]. Journal of Oral Science Research, 2025, 41(2): 85-89.

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