Therapeutic Effect of TPTD on Medication-related Osteonecrosis of the Jaw

doi:10.13701/j.cnki.kqyxyj.2022.08.004

Abstract

Abstract: Teriparatide(TPTD), a synthetic peptide corresponding to the first 34 amino acids of human parathyroid hormone (PTH), has been approved for the treatment of osteoporosis for its anabolic and immunoregulatory effects. Such effects inspired clinicians to dig its potential to rescue jaw bone related disease. Among these, an increasing number of research has shown the therapeutic effect of TPTD on medication-related osteonecrosis of the Jaw (MRONJ). However, the exact pathogenesis of TPTD for treating MRONJ remains largely unknown. This review focuses on the progress of TPTD in the management of MRONJ, investigating its potential value on clinical use.

Key words: Teriparatide, medication-related osteonecrosis of the jaw, treatment

WANG Jiajia, WANG Shaoyi. Therapeutic Effect of TPTD on Medication-related Osteonecrosis of the Jaw[J]. Journal of Oral Science Research, 2022, 38(8): 718-721.

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