Sjögren's Syndrome Complicated with Mucosa-associated Lymphoid Tissue in Parotid: Two Cases Report

doi:10.13701/j.cnki.kqyxyj.2025.03.013

Abstract

Abstract: Mucosa-associated lymphoid tissue (MALT) lymphoma is a type of non-Hodgkin's lymphoma. MALT lymphoma is often secondary to Sjögren's syndrome (SS). This paper reports 2 cases of SS complicated with MALT lymphomain parotid. It is difficult to distinguish parotid MALT lymphoma from common diseases such as mumps and benign tumors of the parotid gland. Clinicians should be vigilant during diagnosis and treatment, since the combination of SS will increase the risk of MALT lymphoma.

Key words: lymphoma, Sjögren's syndrome, parotid

ZHANG Chenyu, LI Juan, KANG Zhuangfei, GU Jianqi. Sjögren's Syndrome Complicated with Mucosa-associated Lymphoid Tissue in Parotid: Two Cases Report[J]. Journal of Oral Science Research, 2025, 41(3): 250-252.

References

[1] Hwang JH, Kim DW, Kim KS, et al. Mucosa-associated lymphoid tissue lymphoma of the accessory parotid gland presenting as a simple cheek mass: A case report[J].Medicine (Baltimore), 2019, 98(36):e17042.
[2] Zhang T, Wu Y, Ju H, et al. Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue in the oromaxillofacial head and neck region: A retrospective analysis of 105 patients[J].Cancer Med, 2020, 9(1):194-203.
[3] Nocturne G, Mariette X. B cells in the pathogenesis of primary Sjögren syndrome[J].Nat Rev Rheumatol, 2018, 14(3):133-145.
[4] Wotherspoon AC, Dogan A, Du MQ. Mucosa-associated lymphoid tissue lymphoma[J].Curr Opin Hematol, 2002, 9(1):50-55.
[5] Dong L, Chen Y, Masaki Y, et al. Possible mechanisms of lymphoma development in Sjögren's syndrome[J].Curr Immunol Rev, 2013, 9(1):13-22.
[6] Papageorgiou A, Ziogas DC, Mavragani CP, et al. Predicting the outcome of Sjögren's syndrome-associated non-hodgkin's lymphoma patients[J].PLoS One, 2015, 10(2):e0116189.
[7] Masaki Y, Sugai S. Lymphoproliferative disorders in Sjögren's syndrome[J].Autoimmun Rev, 2004, 3(3):175-182.
[8] Moisini I, Davidson A. BAFF: a local and systemic target in autoimmune diseases[J].Clin Exp Immunol, 2009, 158(2):155-163.
[9] Szodoray P, Jellestad S, Teague MO, et al. Attenuated apoptosis of B cell activating factor-expressing cells in primary Sjögren's syndrome[J].Lab Invest, 2003, 83(3):357-365.
[10] Su Q, Yu GY. Research progress of salivary glands mucosa-associated lymphoid tissue lymphoma[J].Zhonghua Kou Qiang Yi Xue Za Zhi, 2018, 53(1):54-59.
[11] Isaacson PG. Mucosa-associated lymphoid tissue lymphoma[J].Semin Hematol, 1999, 36(2):139-147.
[12] Bacon CM, Du MQ, Dogan A. Mucosa-associated lymphoid tissue (MALT) lymphoma: a practical guide for pathologists[J].J Clin Pathol, 2007, 60(4):361-372.

[1]	LI Ke, LI Zihui, KOU Jiahao, SUN Guowen. Giant Pleomorphic Adenoma of Left Parotid Gland Malignant Transformation: A Case Report [J]. Journal of Oral Science Research, 2024, 40(7): 654-656.
[2]	WANG Feng, CHEN Xuya, ZHOU Gang, ZHANG Jing. Multidisciplinary Diagnosis and Treatment of Extranodal Nasal Type NK/T Cell Lymphoma with Oral Mucosal Ulcer as the First Manifestation: A Case Report [J]. Journal of Oral Science Research, 2024, 40(3): 275-278.
[3]	FENG Jing, CAI Yang. Extranodal NK/T Cell Lymphoma: A Case Report [J]. Journal of Oral Science Research, 2024, 40(1): 86-88.
[4]	LI Xiang, ZOU Haixiao. Advancement in Endoscope-assisted Parotid Tumours Surgery [J]. Journal of Oral Science Research, 2023, 39(8): 671-674.
[5]	FENG Yongjing, WEN Shanhui, WANG Tiemei, TENG Yuehui, XIA Shu. Clinical and CT Imaging Analysis of Primary Non-Hodgkin Lymphoma of Jaw [J]. Journal of Oral Science Research, 2023, 39(11): 978-981.
[6]	GUO Jiaoyang, SHUI Huahua. Swollen Bilateral Parotids Tissue Caused by Sarcoidosis: A Case Report [J]. Journal of Oral Science Research, 2022, 38(4): 381-382.
[7]	ZHANG Wenxin, Pakezhati·SEYI TI, WANG Tiemei, LIU Shu, ZHANG Lei, Sun Guowen. Predictive Analysis of MDCT Combined with CTA Visualization in Diagnosis of Parotid Tumor [J]. Journal of Oral Science Research, 2022, 38(12): 1134-1138.
[8]	YAN Qinghan, WANG Jiali, CHE Yinfu, YU Tao, TAO Feng, CHEN Lixin, HE Dengqi. Development and Validation of Nomogram for Benign and Malignant Parotid Tumors Combined with Enhanced CT Image Features [J]. Journal of Oral Science Research, 2021, 37(7): 646-650.
[9]	PAN Xiao, HU Ziyang, LIANG Jiahao, ZHANG Lei, LIN Zitong. Manifestation and Analysis of Parotid Malignant Lymphoma with Spiral CT [J]. Journal of Oral Science Research, 2021, 37(7): 651-655.
[10]	YU Fang, CHEN Qiongrong, XIANG Yuanhang, XU Jian. Clinicopathological Analysis of Primary Leiomyosarcoma of Parotid Gland [J]. Journal of Oral Science Research, 2021, 37(6): 519-522.
[11]	QIAN Yemei, WANG Weihong, ZHU Jin, ZOU Zhirong, YU Lifu, LUO Lei. Parotid and Temporal Defect Restoration with Submental Musculocutaneous Island Flap [J]. Journal of Oral Science Research, 2021, 37(12): 1115-1118.
[12]	YU Chenglong, YANG Yong, XUE Boyuan, LI Jianwei, GAO Hong, SONG Jiaojiao, LIU Guoqi, ZUO Jinhua. Significance of Laminin, Integrin α6β1, and Focal Adhesion Kinase in Parotid Atrophy Induced by Main Duct Ligation in Rats [J]. Journal of Oral Science Research, 2021, 37(12): 1119-1124.
[13]	WANG Songjie, ZHAO Junfang, PENG Yanhui, ZHA Zhian, WANG Qiuxiang, SUN Qiang. Clinical Manifestations and Imaging Characteristics of Parotid Secretory Carcinoma [J]. Journal of Oral Science Research, 2021, 37(11): 1039-1041.
[14]	TAO Boqiang, LIU Yingkun, LI Yuyang, MIN Fenghe, LIU Huimin,YANG Zhijing, LIU Weiwei. Comparative Analysis of Sternocleidomastoid Muscle Flap and Oral Repair Membrane in Postoperative Treatment of Benign Parotid Tumor [J]. Journal of Oral Science Research, 2020, 36(11): 1036-1039.
[15]	HONG Xiaowei, SUN Guowen, WANG Zhiyong, ZHU Feng, LI Wei. Application of Anterior Auricular Extension Incision in Resection of Accessory Parotid Gland Tumors [J]. Journal of Oral Science Research, 2020, 36(10): 912-914.