Abstract: Blue rubber bleb nevus syndrome (BRBNS) is a rare systemic vascular malformation-related disorder that primarily affects the skin, gastrointestinal tract, and central nervous system. Due to the potential risk of gastrointestinal and cerebral hemorrhage, it is crucial for oral physicians to recognize and refer patients to the appropriate departments to improve prognosis and enhance their quality of life. This article reports a case of BRBNS associated with vascular malformations in the maxillofacial region, and discusses its clinical features, diagnosis, and treatment strategies in conjunction with relevant literature. The aim is to raise awareness among oral physicians about this condition and to prevent missed or misdiagnoses.

Key words: maxillofacial vascular malformations, blue rubber bleb nevus syndrome, gastrointestinal vascular malformations, clinical diagnosis and treatment, case report