Research Progress in Clinical Diagnosis and Treatment of Oral Verrucous Carcinoma

doi:10.13701/j.cnki.kqyxyj.2018.07.001

Abstract

Abstract: Oral verrucous carcinoma (OVC), a malignant tumor, has distinctive and unique histological changes and biological behaviors. The clinical manifestations of OVC often appear as a slowly increasing verrucous off-white growth, which primarily occurs in the maxillary and mandibular gums and in the nearby mucosal folds. In this review, we focused on the research progress and gave insight into the etiology, clinical manifestation and classification, oral pathology, diagnosis and differential diagnosis, treatment, and follow-up of oral verrucous carcinoma, so as to serve as a spur to stimulate more worthy and valuable contributions.

Key words: Oral, Oral verrucous carcinoma, Oral malignant tumor, Clinical diagnosis and treatment

TANG Zhan-gui, CHEN Juan. Research Progress in Clinical Diagnosis and Treatment of Oral Verrucous Carcinoma[J]. Journal of Oral Science Research, 2018, 34(7): 687-691.

References

[1] Ackerman LV. Verrucous carcinoma of the oral cavity [J]. Surgery,1948, 23(2):670-678
[2] 王瑛, 吴奇光, 郑麟蕃. 口腔黏膜疣状癌的临床病理学研究[J].中华口腔科杂志,1985,20(3):65-68
[3] 邹萍,唐瞻贵,冯德云,等.人乳头状瘤病毒16/18型、p53、p16蛋白在口腔疣状癌中的表达[J].口腔颌面外科杂志,2003,13(3):211-215
[4] 邹萍,唐瞻贵,冯德云,等. 人乳头状瘤病毒16/18型在口腔疣状癌中的表达及意义[J].现代口腔医学杂志,2004,18(1):5-8
[5] De Socio GV, Bidovanets O, Tomassini GM, et al. Human papilloma virus-associated lips verrucous carcinoma in HIV-infected male [J]. J Int Assoc Provid AIDS Care, 2017, 16(4):324-326
[6] Gupta S, Kumar K, Raviprakash SM, et al. Ackerman's tumor of the oral cavity: A study of four cases with its conglomerate appearance [J]. J Dent Specialties, 2015, 3(4):92-95
[7] Luo JS, Tang ZG, Li L, et al. Verrucous carcinoma associated with oral submucous fibrosis that gradually transforms to squamous cell carcinoma: a rare case report[J]. Int J Clin Exp Pathol, 2016, 9(11):11838-11842
[8] Shafer WG. Verrucous carcinoma[J]. Int Dent J, 1972, 22(4):451-459
[9] Rodrigues J, Vaz OP, Salelkar RS, et al. A rare case of verrucous carcinoma on the dorsum of the tongue [J]. Int J Adv Case Rep, 2015, 2(2):530-531
[10] 唐瞻贵,王月红.口腔疣状癌研究进展[J].中华口腔医学杂志:电子版, 2010, 4(5):425-432
[11] Peng Q, Tang ZG, Wang YH, et al. Oral verrucous carcinoma: From multifactorial etiology to diverse treatment regimens (Review) [J]. Int J Oncol, 2016, 49(1):59-73
[12] Fang XD, Liu OS, Tang ZG. Oral verrucous carcinoma: a retrospective clinical study of 29 Chinese patients [J]. Int J Clin Exp Med, 2017, 10(3):5228-5232
[13] Gokavarapu S, Rao S LM, Tantravahi US, et al. Oral hybrid verrucous carcinoma: A clinical study [J]. Indian J Surg Oncol, 2014, 5(4):257-262
[14] Karagozoglu KH, Buter J, Leemans CR, et al. Subset of patients with verrucous carcinoma of the oral cavity who benefit from treatment with methotrexate [J]. Brit J Oral Max Surg, 2012, 50(6):513-518
[15] Liu O, Zhang HX, Tang ZG, et al. Stereology study of oral verrucous carcinoma [J]. J BUON, 2012, 17(2):343-349
[16] 唐瞻贵,谢晓莉,粟红兵,等.口腔黏膜疣状癌电镜观察及其临床病理的联系[J].湖南医科大学学报,1996,21(3):262-264
[17] Zhu LK, Ding YW, Liu W, et al. A clinicopathological study on verrucous hyperplasia and verrucous carcinoma of the oral mucosa [J]. J Oral Patho Med, 2012, 41(2):131-135
[18] Grover S, Jha M, Sharma B, et al. Verrucous hyperplasia: case report and differential diagnosis [J]. Sultan Qaboos Univ Med J, 2017, 17(1):e98-e102
[19] Paral KM, Taxy JB, Lingen MW. CD34 and α smooth muscle actin distinguish verrucous hyperplasia from verrucous carcinoma [J]. Oral Surg Oral Med Oral Pathol, 2014, 117(4):477-482
[20] Habiba U, Kitamura T, Yanagawa MA, et al. Cytoplasmic expression of HuR may be a valuable diagnostic tool for determining the potentialor malignant transformation of oral verrucous borderline lesions [J]. Oncol Rep, 2014, 31(4):1547-1554
[21] Garcia NG, Oliveira DT, Hanemann JA, et al. Oral verrucous carcinoma mimicking a chronic candidiasis: a case report [J]. Case Rep Oncol Med, 2012, 2012:190272
[22] 唐瞻贵,谢晓莉,李晋芸,等.口腔疣状癌的误诊研究[J].临床口腔医学杂志,2003,19(8):474-475
[23] Dalirsani Z, Falaki F, Mohtasham N, et al. Oral verrucous carcinoma and ameloblastoma: a rare coincidence [J]. Iranian J Otorhinolaryngol, 2015, 27(2):159-163
[24] 黄谢山,谈顺.口腔颌面疣状癌误诊1例[J].口腔医学研究,2010,26(1):107-107
[25] Verma DK, Bansal S, Gupta D, et al. Neck dissection in verrucous carcinoma: A surgical dilemma [J]. IJSS Case Rep Rev, 2015, 1(1):42-45
[26] Yu CH, Lin HP, Cheng SJ, et al. Cryotherapy for oral precancers and cancers [J]. Formos Med Assoc, 2014, 113(5):272-277
[27] Yeh CJ. Treatment of verrucous hyperplasia and verrucous carcinoma by shave excision and simple cryosurgery [J]. Int J Oral Maxillofac Surg, 2003, 32(3):280-283
[28] Kwon HB, Choi YS, Lee JH, et al. Treatment of verrucous carcinoma of the lower lip with topical imiquimod (Aldara^®) and debulking therapy [J]. Ann Dermatol, 2011, 23(1):S68-S71
[29] Candau-Alvarez A, Dean-Ferrer A, Alamillos-Granados FJ, et al. Verrucous carcinoma of the oral mucosa: An epidemiological and follow-up study of patients treated with surgery in 5 last years [J]. Med Oral Patol Oral Cir Bucal, 2014, 19(5):e506-e511
[30] Wu CF, Chen CM, Shen YS, et al. Effective eradication of oral verrucous carcinoma with continuous intraarterial infusion chemotherapy [J]. Head Neck, 2008, 30(5):611-617