Abstract: Objective: To compare the level of procalcitonin (Pro-CT) in whole saliva in diabetic patients with periodontitis, simplex diabetic patients, patients with simplex periodontitis and healthy subjects, and to analyze its relationships with the control on blood glucose and severity of periodontal disease. Methods: By case-control study, there were 24 cases of patients with diabetes accompanied with periodontitis in DM+CP group, 30 cases of simple diabetic patients (DM group), 30 cases of patients with simple periodontitis (CP group) and 30 cases of healthy people. The resting whole saliva of subjects was collected. The level of Pro-CT in whole saliva was detected using enzyme-linked immunosorbent assay (ELISA). Results: The level of Pro-CT in whole saliva in DM+CP group was significantly higher than that in other three groups, and the difference has statistical significance (P<0.01). The level of Pro-CT in whole saliva increased with the increasing severity of periodontitis, increased with not ideal control on blood glucose, and the difference has statistical significance; The level of Pro-CT in whole saliva showed a positive correlation with probing depth (PD), probing bleeding index (BI), attachment loss (AL) and number of missing teeth. Moreover the degrees of correlation from high to low were successively PD, BI, AL and the number of missing teeth. The difference was statistically significant (P<0.05). Conclusion: Micro inflammatory state in patients with diabetes may be associated with periodontal inflammation. The level of Pro-CT in whole saliva was affected by both periodontitis and systemic factors.

Key words: Diabetes Periodontitis , Whole saliva , Inflammatory factor