Journal of Oral Science Research

Histological Observation for Osseointegration of Delayed Implantation with Bio-Oss Following Tooth Extraction.

Qiu Ze-wen, LIU Hui-ying, ZHONG Wei-jian, et al

2015, 31(1): 1-3.

Abstract ( 179 )

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Objective: To evaluate the influence on the osseointegration of delayed implantation of dental implant with Bio-Oss artificial bone following tooth extraction. Methods: The bilateral 3rd and 4th mandibular premolars of 6 adult, healthy, male and female dogs were extracted. We randomly selected 2 extraction sockets in each dog to be filled with Bio-Oss (the experimental group); the other 2 extraction sockets which were not treated served as the control group. Dental implants were inserted into the alveolar bone of the experimental group and the control group 3 months after Bio-Oss placement. The osteogenic activity in the bone around the implants was assessed by evaluating the histological morphology and estimating histomorphometric parameters 3 and 6 months after delayed implantation. Results: After the 3 months, Goldner's trichrome staining analysis showed that the bone-implant contact rate and mineralized bone area around the implant were significantly higher in the experimental group (75.98%±8.97% and 69.52%±9.63%, respectively) than those in the control group (56.13%±8.18% and 52.82%±7.25%, respectively, P<0.05). However, no significant difference was found between the 2 groups after 6 months. Conclusion: These data indicate that alveolar ridge preservation by using Bio-Oss placement can promote osseointegration of delayed implantation, and may be a promising option for clinical use.

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Construction of hBMP-7 Gene Recombinant Adenovirus and Its Expression after Infecting dMSCs.

WANG Wei-guo, LI Wei-qi, DENG Yong-hua, et al

2015, 31(1): 4-6.

Abstract ( 181 )

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Objective: To observe the repair of mandibular defects with tissue engineering bone using coral hydroxyapatite and dog marrow stromal cells (dMSCs) which was transfected by recombinant adenovirus vector in vitro carrying human bone morphogenetic protein-7 (hBMP-7) gene. Methods: After the compound of coral hydroxyapatite composite scaffold material and dMSCs transfected with high-level expression hBMP-7 adenovirus vector constructed by AdEasy adenovirus expression system was implanted in mandibular defects of dogs, the reparation situation of mandibular defection was observed 4 weeks and 8 weeks after operation respectively. Results: Significant new bone formation was found in the naked mouse skin and bone defect by gross observation, X-ray examination and histological observation of the constructed tissue engineering bone. Conclusion: Constructed tissue engineering bone carrying hBMP-7 gene was found to format more volume bone tissue, and could effectively repair mandibular defect.

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Construction and Odontogenic Effects on Rat Bone Marrow Mesenchymal Stem Cells of Bone Morphogenetic Protein4 Lentiviral Vector.

WANG Huan-huan, HU Yang, HANG Xiang-zhen, et al

2015, 31(1): 7-10.

Abstract ( 216 )

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Objective: To construct lentiviral vector carrying bone morphogenetic protein4, and to detect the odontogenic effects on rat bone marrow mesenchymal stem cells for tissue- engineered tooth seed cells. Methods: hBMP4 cDNA was gained by RT-PCR from the mRNA ,which was extracted from mature human placenta. Then it was cloned into plenti6/v5-D-TOPO vector. Lentiviral vectors carrying BMP4 were constructed to transfect rat bone marrow mesenchymal stem cells(BMSCs). The RNA was extracted using real-time quantitative PCR to detect the changes mRNA levels of collagen I, enamel protein,dentin matrix protein 1, and homeobox gene 1. And the proliferation ability of BMSCs was detected with MTT method before and after transfection. Results: After transfection, mRNA levels of collagen I, enamel protein and dentin matrix protein 1 were higher, and the difference was statistically significant (P<0.05),but the mRNA levels of homeobox gene 1 were not significant different, and the proliferation ability was increased. Conclusion: BMP4 is able to improve the proliferation and odontogenic differentiation potential of BMSCs in vitro.

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Capacity of Hesperidin, Limonene and Tea Polyphenols on Sequestering Free Radical.

LIU Ya-li, CHEN Si-jia, ZHANG Chen, et al

2015, 31(1): 11-14.

Abstract ( 229 )

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Objective: To study the capacity of hesperidin, limonene and tea polyphenols on sequestering 1, 1 diphenyl-2-trinitrobenzene hydrazine (DPPH·) and hydroxyl free radical (·OH) . Methods: UV-Vis spectrum analysis method was used to determinate the three natural products on DPPH· and ·OH free radical scavenging. Results: The three natural products in the experimental concentration range have the capacity to remove the free radicals, the removal of effect increases with the concentration. The capacity of hesperidin (IC₅₀=0.097, 0.011) is stronger than the limonene (IC₅₀=0.00236, 0.0004), tea polyphenol (IC₅₀=0.0144, 0.0009) on DPPH· and ·OH scavenging. Conclusion: The antioxidant capacity of hesperidin is stronger than tea polyphenol and limonene in vitro.

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Alizarin red and Alcian Blue Double Staining for the Whole Observation of Development of Mouse Mandible.

ZHAO Yi-song, ZHONG Hui-min, HE Zhi-wei, et al

2015, 31(1): 15-17.

Abstract ( 555 )

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Objective: To explore the feasibility of using the alizarin red/ alcian blue double staining to observe the whole development of mouse mandible. Methods: Alcian blue and alizarin red solution were used to double stain the E15.5, E16.5, E18.5 and P90 mouse mandibular skeleton. We observed the whole development of mandible, especially focused on the Meckel's cartilage and condylar cartilage. Results: The bone and cartilage could be stained as red or blue respectively. The morphology of the developmental mandible could be clearly observed under the stereo microscope. The Meckel's cartilage was not tightly connected to the surrounding tissues. The condylar cartilage was independent of the Meckel's cartilage, and was tightly connected to the mandibular periosteum. Conclusion: Using the alizarin red/alcian blue double staining could successfully observe the whole development process of mouse mandible. The Meckel's cartilage may not directly take part in the bone formation of mandible, and the condylar cartilage may originate from the mesenchymal cell in tail end of mandible.

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Effect of co-culture of BMP-2 and bFGF Transfected Rat Bone Marrow Stem Cells and Germ Cells on Tooth Gene.

WU Wei-wei, HU Yang, HE Hui-yu, et al

2015, 31(1): 18-22.

Abstract ( 155 )

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Objective: To observe the bone morphogenetic protein -2 (BMP-2) and (or) basic fibroblast growth factor (bFGF) transfected rat bone marrow stem cells (BMSCs) and germ mixed culture cells in vitro effects on dentin matrix protein 1 (DMP1), ameloblastin (AMBN), Ⅰ collagen (collagen-Ⅰ), homeobox gene 1 (DLX1)'s. Methods: From gene expression and protein levels by real-time quantitative PCR and Western blot to determine the level of BMP-2 and (or) the impact of bFGF on four genes. Results: The control group, bFGF group, BMP-2 group and bFGF / BMP-2 group among the four groups, AMBN, COLLAGEN-Ⅰ, DLX1, DMP1 genes were significantly different (P<0.05) in the expression of mRNA and protein levels. Conclusion: BMP2 and bFGF have synergistic interaction, BMP2 / bFGF / BMSCs / germ cells can be constructed as seed cells for tissue engineering of teeth.

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Effect of Occlusal Interference on Endoplasmic Reticulum Stress and ER Stress-mediated Apoptosis in Condylar Chondrocytes of Rat.

CAI Chang-an, ZHANG Li

2015, 31(1): 23-26.

Abstract ( 169 )

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Objective: To study the effects of occlusal interference on endoplasmic reticulum stress and ER stress-mediated apoptosis in mandibular condylar chondrocytes of Sprague-Dawley (SD) rat. Methods: In experimental groups,the malocclusion was created by bonding the harmful prosthesis on first molar of upper jaw. Animals were sacrificed at 4, 8 and 12 weeks later. Toluidine blue and hematoxylin-eosin (HE) staining were carried out to study the morphological changes of the condylar cartilage.The ultrastructure of chondrocyte was observed by transmission electron microscopy. Immunohistochemical(IHC)staining was performed to detect the levels of expression of GRP78 and Caspase-12 in the condylar cartilages. Results: In the condylar cartilages of experimental groups, the matrix was degraded and the chondrocytes density decreased significantly. Endoplasmic reticulum expanded and fractured into parts. Comparing to the control group, the expression of GRP78 increased in all time points (P<0.05,P<0.05,P<0.01), while the expression of Caspase-12 increased at the end of 8 and 12-weeks. Conclusion: The endoplasmic reticulum stress and ER stress-mediated apoptosis occurred in the condylar chondrocyte of rat with occlusal interference, which should play an important role in the degradation of condylar cartilage.

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Animal Model of Reconstruction of Beagle Large Segment of Mandibular Defect with Allogenic Mandibular Scaffold and Autologous Mesenchymal Stem Cells.

LIU Chang-kui, TAN Xin-ying, LUO Jin-chao, et al

2015, 31(1): 27-30.

Abstract ( 170 )

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Objective: To build a model of repairing large segmental of mandibular defect using engineering bone with allogenic mandibular scaffold and autologous mesenchymal stem cells. Methods: Twenty-four beagles, weighing 10 to 15 kg, received 30 mm bone surgical defects in each left body of the mandible. The Beagles were divided into 2 groups. The bony defect of the control group (12 beagles) were reconstructed using allograft only. The experimental group (12 beagles) were reconstructed using allogenic mandibular scaffold ioaded autologous mesenchymal stem cells. Beagles from each treatment were sacrificed at 4 weeks, 12 weeks, 24 weeks, or 48 weeks after surgery. Computed tomography were used to evaluate the reconstruction of the defect. Results: Results showed that the experimental group and the control group , allogeneic bone could heal with autologous bone, and could be gradually replaced by autogenous bone. A year later, the allogenic mandibular scaffold of the experimental group were completely replaced by new bone. But the size of the new bone was smaller than original allogenic scaffold. In the control group, the new bone was formed in both ends. The size of the allogenic scaffold wasn't changed compared with original allogenic scaffold. Conclusion: The successful establishment of animal models provides basis for further study the worth and the mechanism of allogeneic bone scaffold combined with autologous bone marrow mesenchymal stem cells to repair segmental mandibular defect.

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Animal Experiment of PDLSC Cultured on TCP/Chitosan Scaffold in Vivo.

ZHONG Zhi-hua, SHI Bin, ZHOU Xian-lue

2015, 31(1): 31-33.

Abstract ( 175 )

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Objective: To test TCP/Chitosan scaffold that PDLSC were cultuled. Methods: We prepared three kinds of TCP/Chitosan scaffolds, cultured PDLSC on TCP/Chitosan scaffold for 24 hrs, and then transplanted it subcutaneously into athymic mice. Implants were taken out after 4 weeks and stained by HE and Col-Ⅰ. Then we observed them by lightscope. Results: PDLSC grow well on TCP/Chitosan scaffold. Degradation rate of TCP/Chitosan scaffold was lower than pure Chitosan scaffold. Col-Ⅰ was observed in three kinds of scaffolds. Conclusion: TCP/Chitosan scaffold is good for culturing PDLSC.

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Study of Genetic Polymorphism in Streptococcus Mutans Clinical Isolates of Surface Protein A-region of Uighur Different Caries Sensitive Children.

LIAN Bing-jie, LIU Zhen-hua, ZHAO Jin

2015, 31(1): 34-37.

Abstract ( 158 )

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Objective: To analyse the relationship between genetic polymorphism and its adhesion ability in Streptococcus mutans clinical isolates of surface protein A Uygur high caries and caries-free children. Methods: Uighur children high caries group ( dmft ≥5) and caries-free group ( dmft=0) were performed clinical strains of Streptococcus mutans adhesion test by bacteria adherent method. We selected the adhesion ability of stronger and weaker strains. The genome DNA was extracted, and the spaP-a was amplified by PCR .Genetic diversity was assessed by restriction fragment-length polymorphism(RFLP) with restriction endonucleases Hae Ⅲ. Results: Adhesion ability of high-caries group was stronger than the caries-free group(33.92 8.79%v. s. 27.53 7.45%), the difference was statistically significant (P<0.05). Two different patterns A and B of spaP-a RFLP among strains were revealed after the amplified product was digested with Hae Ⅲ . The distributions of two genotypes (A and B) in the clinical strains with different adherent abilities differed significantly(P<0.05). A genotype was the majority of the high adhesion force group. Genotype B was mostly in the low adhesion of group. The sequencing DNA testified that the specific base mutation would lead to multiple kinds of genotype resulted. Conclusion: Uighur different caries sensitive children of Streptococcus mutans clinical strains spaP - a gene with genetic polymorphism may be one of the reasons for a discrepancy between the its adhesion ability.

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Proliferation and Osteogenic Differentiation of Human Umbilical Cord Mesenchymal Stem Cell in Chitosan Thermosensitive Hydrogel.

WANG Yi-bo, LI Yun-peng, HOU Rui, et al

2015, 31(1): 38-40.

Abstract ( 168 )

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Objective: To investigate the proliferation and osteogenic differentiation of human umbilical cord mesenchymal stem cells in chitosan thermosensitive hydrogel. Methods: Human umbilical cord mesenchymal stem cells were isolated and cultured in vitro. The chitosan thermosensitive hydrogel was visualized by scanning electron microscopy. Then the cells were cultured in chitosan thermosensitive hydrogel extracts and given osteogenic induction. The proliferation was measured by MTT assay. Alizarin red staining at 21d was performed to assess the osteogenic differentiation potential of hUCMSCs. Results: In chitosan thermosensitive gel, the proliferation of hUCMSCs was similar with those in common medium, and there was no significant difference. Alizarin red staining was positive with formation of calcium nodules after osteogenic induction (21d). Conclusion: HUCMSCs could proliferate and have osteogenic differentiation potential in chitosan thermosensitive hydrogel.

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Causative Gene Analysis of Chinese Hypohidrotic Ectodermal Dysplasia Pedigrees.

LIU Yu, YIN Wei, BIAN Zhuan, et al

2015, 31(1): 41-44.

Abstract ( 153 )

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Objective: To analyze genetic and phenotypic characters as well as the causative gene of one Chinese hypohidrotic ectodermal dysplasia (HED) pedigree. Methods: The pedigree was reported through the identified proband. All family members were investigated through clinical examination and pedigree analysis. The whole ORF nucleotide sequence of EDA, EDAR and EDARADD were analyzed by direct sequencing. Results: The proband male patient has characteristic phenotype of HED. There was no mutation in EDA, EDAR and EDARADD gene. Conclusion: The patient showed similar phenotype with the previous report. But this study did not get the causative gene.

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Comparative Study of Curative Effectiveness of Mandibular Retrognathia Cases with Traditional Twin-block or Stepwise Twin-block Appliance.

Gulibaha Maimaitili, CHEN Chong, CHEN Wen-jun,et al

2015, 31(1): 45-47.

Abstract ( 179 )

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Objective: To compare clinical curative effect on Class Ⅱ with mandibular retrognathia by the two Twin-block appliance. Methods: 13 mandibular retrusion case with mixed dentition or early permanent dentition were selected, they received modified Twin-block treatment. According to the case control principle 13 case with Twin-block treatment were selected as the control group .The Cephalometrics analysis was performed before and after treatment for oberserving 18 hard tissue variables. Results: In the experiment group, the SNB increased, the Y axis decreased, MP-SN, FH-MP increased, the jaw and chin position relative to the skull base of change was obvious .Early treatment with two Twin-block appliance were effective in overjet and correction. Conclusion: It was almost the same effect for Class II Division 1 mandibular retrusion patients using Twin block or modified Twin-block in the early treatment. But the modified Twin-block appliance was more suitable for curing Angle’s class II division 1 mandibular retrusion cases.

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Design, Manufacture and Application of Individual Mandible Titanium Alloy Implant Based on Three Dimensional Printing.

ZHANG Qing-fu, LIU Gang, LIU Guo-qin

2015, 31(1): 48-51.

Abstract ( 284 )

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Objective: To investigate the design, manufacture and application of individual titanium alloy mandible implant based on three dimensional printing of titanium alloy. Methods: A patient with large mandible body, angle and ramus ameloblastomas was given a spiral CT scanning. Based on the CT scanning, the pathological changed mandible was reconstructed, and after which simulated resection, individual mandible implant design and optimization was carried out. When the design of the implant was finished, the data of the implant was input into the three dimensional printing machine and the individual mandible implant was manufactured. During the operation, when the pathological mandible was removed, the mandible implant was accurately assembled immediately. Results: The titanium alloy mandible implant designed and manufactured based on three dimensional printing was highly individual anatomic emulation, and highly inosculated with healthy mandible. The shape and the function were renewed ideally. Conclusion: Three dimensional printing of titanium alloy made the design, manufacture and clinical application of highly individual anatomic emulated mandible implant realism. Optimized design could made the titanium alloy mandible implant has realistic biomechanical capability, light weight and right precision.

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CCND1 G870A Polymorphism Confer Susceptibility to Oral Cancer: A Meta-Analysis.

XIE Li-ming, YAN Jin, SHEN Guo-fang, et al

2015, 31(1): 52-56.

Abstract ( 180 )

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Objective: To evaluate the association of Cyclin D1 (CCND1) G870A genetic polymorphism with susceptibility to oral cancer. Methods: A literature search of PubMed, Chinese BioMedical, Wanfang, VIP, CNKI databases was conducted from inception through July 1st, 2013. Crude odd ration (OR) with 95% confidence intervals (CI) was calculated. Results: Ten case-control studies were assessed, including 1,622 oral cancer patients and 1,859 healthy controls. Meta-analysis showed that mutant A allele of CCND1 G870A polymorphism was associated with increased risk of oral cancer (A vs. G: OR=1.23, 95%CI: 1.02-1.49, P=0.033; AA+AG vs. GG: OR=1.39, 95%CI: 1.03-1.87,P=0.031; AA vs. AG+GG: OR=1.32, 95%CI: 1.13-1.55,P=0.001; AA vs. GG:OR=1.47, 95%CI: 1.00-2.16,P=0.049; AA vs. AG:OR=1.22, 95%CI: 1.03-1.44,P=0.020). Further stratified analyses indicated that this association was more significant in Asians and smokers, but not in Caucasians and non-smokers. Conclusion: This meta-analysis provides strong evidence that CCND1 G870A polymorphism may be associated with oral cancer risk, especially among Asians and smokers. However, further large-scale studies are needed to determine the association of CCND1 G870A genetic polymorphism with susceptibility to oral cancer.

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Clinical Application and Pain Perception of Duraphat for Patients with Chronic Periodontitis During Periodontal Initial Treatment.

LUO Tie-zhu, LIU Ming-hai

2015, 31(1): 57-59.

Abstract ( 164 )

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Objective: To investigate the effect of duraphat to treat hypersensitivity after subgingival scaling. Methods: 80 patients with chronic periodontitis were randomly divided into subgingival debridement(Group A) and subgingival debridement with Duraphat(Group B). Each patient had to have at least two sites with probing depths of >4mm in each quadrant. Compare PD, BOP, CAL changes and the degree of treatment discomfort with VAS values of groups A and B at baseline, 1 month and 3 months after treatment. According to the periodontal probing depth (PD), patients are also randomly divided into two subgroups: subgroup A with PD >4mm and subgroup B with PD more than 6mm. Duraphat and ordinary toothpaste without desensitization ingredients are used separately after scaling. The indexes of VAS were recorded immediately, 1 month and 3 months later to evaluate the degree of tooth sensitivity. Results: Probing pocket depth, clinica attachment level and bleeding index improved both groups, but the patients perceived less pain with Duraphat during therapy. Conclusion: The duraphat has ideal effect in treating chronic periodontitis and can reduce teeth hypersensitivity after subgingival scaling.

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Related Articles Analysis in the Web of Science about Rapid Tooth Movement and Distraction Osteogenesis.

YANG Chuan, ZU Qing, CHEN Wen-jun

2015, 31(1): 60-63.

Abstract ( 137 )

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Objective: Through the rapid tooth movement and distraction osteogenesis of the related articles of literature, To summarize the status of current measurement analysis and research field. Methods: In the United States intelligence institute (ISI) Science development Web of Science network database as data sources on the base of the Rapid tooth movement and distraction osteogenesis through SCI included periodontal membrane technique the relevant article papers, from the paper published time distribution, the national area distribution, the agency distribution, journal distribution and cited frequency distribution and so on statistics and analysis. Results: There were 1950/2011 were fast moving periodontal teeth and zhang osteogenesis technique the relevant article 20, nearly eight years literature to the rapid growth of the article published in China most, total 5 articles. Conclusion: Periodontal membrane brought weeks with distraction osteogenesis in three dimension finite element related articles in this field of research and development tendency of dynamic China research and periodontal weeks with Distraction osteogenesis in the change in the Rapid tooth movement distraction osteogenesis finite element method can be used for reference to provide the reference suggestion.

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Detection of Concentration of Pro-CT in Whole Saliva in Patients with Periodontitis Accompanied with Diabetes and its Significance.

DU Jun, HE Hui-yu, Maimaiti Yasen

2015, 31(1): 64-68.

Abstract ( 156 )

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Objective: To compare the level of procalcitonin (Pro-CT) in whole saliva in diabetic patients with periodontitis, simplex diabetic patients, patients with simplex periodontitis and healthy subjects, and to analyze its relationships with the control on blood glucose and severity of periodontal disease. Methods: By case-control study, there were 24 cases of patients with diabetes accompanied with periodontitis in DM+CP group, 30 cases of simple diabetic patients (DM group), 30 cases of patients with simple periodontitis (CP group) and 30 cases of healthy people. The resting whole saliva of subjects was collected. The level of Pro-CT in whole saliva was detected using enzyme-linked immunosorbent assay (ELISA). Results: The level of Pro-CT in whole saliva in DM+CP group was significantly higher than that in other three groups, and the difference has statistical significance (P<0.01). The level of Pro-CT in whole saliva increased with the increasing severity of periodontitis, increased with not ideal control on blood glucose, and the difference has statistical significance; The level of Pro-CT in whole saliva showed a positive correlation with probing depth (PD), probing bleeding index (BI), attachment loss (AL) and number of missing teeth. Moreover the degrees of correlation from high to low were successively PD, BI, AL and the number of missing teeth. The difference was statistically significant (P<0.05). Conclusion: Micro inflammatory state in patients with diabetes may be associated with periodontal inflammation. The level of Pro-CT in whole saliva was affected by both periodontitis and systemic factors.

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Clinical Evaluation of the Quality of Root Canal Obturation.

DAI De-hua, WANG Xuan, DAI Jing, et al

2015, 31(1): 69-71.

Abstract ( 215 )

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Objective: To evaluate the role of standardized manipulation in endodontics by comparing the quality of root canal filling before and after standardized manipulation training, according to the digital radiography. Methods: Using stratified random sampling method a total of 598 endodontically treated teeth with 1208 roots, which were completed by four dentists, were retrospectively studied. The quality of root canal filling was analysed radiographically according to the length, density, and taper of root fillings, meanwhile the presence of overfilling and ledge formation was recorded for each root canal. Results: The overall percentages of adequate teeth filling and root canals filling after taking standardized manipulation training were 64.9% and 72.6% respectively, which were significantly higher than those before taking standardized manipulation. Meanwhile, regardless of anterior teeth, premolars or molars, the percentages of adequate teeth filling and root canals filling after taking standardized manipulation were significantly higher. The overall rate of ledge formation before taking standardized manipulation were 20.7%, which was declined to 14.2% after taking standardized manipulation. The difference between the two groups was statistically significant. Conclusion: The quality of root canal filling was improved greatly after taking standardized manipulation.

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Evaluation of Clinical Efficacy of Three Types of Periodontal Splints.

QIU Ya-fei, WANG Wen-ling, LI Ya-juan, et al

2015, 31(1): 72-75.

Abstract ( 204 )

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Objective: To compare the clinical effects of wrought wire, casting, and telescopic crowns splints on treatment of patients with severe periodontitis. Methods: Sixty eligible patients were included and randomized into 3 groups: wrought wire splints group, casting, and telescopic crowns group. Twenty subjects were in each group. All patients went through sequenced periodontal initial therapy, and then were treated by assigned type of splints. All loosen teeth were fixed. Both supragingival and subgingival scaling was maintained twice a year for the subjects. The clinical parameters including pocket probing depth, clinical attachment loss and tooth mobility were examined and recorded at baseline, 6, 12 and 24 months after splints treatment, respectively. Results: After the treatment of periodontal splints, the probing depth, clinical attachment loss and tooth mobility of the assessed teeth in each group were significantly improved (P<0.05). Notably, the clinical efficacy of telescopic crowns group was superior to the casting and wrought wire groups (P<0.05). The casting group showed significant improvement in terms of all tested parameters comparing with the wrought wire group at 6, 12 and 24 months visit, respectively. Conclusion: All three types of periodontal splints are beneficial in maintaining periodontal health, and can effectively fix the loose teeth, among which the telescopic crowns splints show the most benefit in the treatment of periodontitis.

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Clinical Investigation of Stabilization Splint in the Treatment of Anterior Disc Displacement Without Reduction.

QI Dong-yuan, MA Jun-tao, ZHANG Rui, et al

2015, 31(1): 76-77.

Abstract ( 177 )

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Objective: To analyse the efficacy of the stabilization splint in the treatment of anterior disk displacement without reduction. Methods: Thirty-six patients (29 females, 7 males) of anterior disk displacement without reduction were treated with stabilization splint.The period of treatment was 3 months. Visual analog pain scale (VAS) and mouth opening were recorded before and immediately after the insertion of splint. T-test for matched pairs was used to assess the effectiveness of the splint. Results: After 3-month-treatment, VAS reduced from 5.66±1.28 to 1.46±1.14 and mouth opening increased from 26.93±2.64mm to 38.35±2.04mm. Analysis showed a statistically significant difference of P<0.001. However, postinsertion MRI showed no recapture of disks. Conclusion: The stabilization splint is effective in treating anterior disk displacement without reduction ,despite its effect is helping bilaminar zone of temporomandibular joint remodeled to function as a disc, not recapture of disks.

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Root Resorption during the Alignment and Leveling Phase of Orthodotic Treatment in the Who Have Periondontal Diseases Patients.

ZHANG Ke-ke, GENG Yu-dong, YAN Bo, et al

2015, 31(1): 78-80.

Abstract ( 176 )

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Objective: To compare the external apical root resorption of patients with and without periodontitis during the alignment and leveling phase of orthodontic treatment. Methods: 60 adults malocclusion patients were chosen, 30 were periodontal disease,and 30 were not, All did not need extraction and used MBT technique. The magnitude of EARR were detected by using digital paralleling technique. The films were obtained before the orthodontic treatment(T0) ,1(T1)and 6(T2) months after the orthodontic treatment. We compared the magnitude of EARR in different phases between the two groups. Results: EARR occurred in both groups during the alignment and leveling phase, but there was no statistical difference in the magnitude of EARR X(0-2),X(0-1)between the two groups. Conclusion: EARR occurred in both groups, however, the difference was not significant.

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Clinical Efficiency of Mandibular Reconstruction Using Vascularized Iliac Crest Flap and Fibular Flap.

LIN Wen-qing, HU Yan-ping, ZHANG Wen-feng

2015, 31(1): 81-84.

Abstract ( 209 )

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Objective: To evaluate the clinical effect of mandibular reconstruction used vascularized iliac crest and fibular flap, and to compare their advantages and disadvantages. Methods: We conducted a retrospective analysis of 44 patients who underwent mandibular reconstruction, 20 patients with iliac crest and 24 with free fibula. The results of contour and function, complications of recipient and donor sites were analyzed according to the clinical data and follow-up. Results: All flaps survived. There was no significant difference for contour and function between the vascularized iliac crest flap and free osteofasciocutaneous fibula flap, but the length of graft bone had significant discrepancy between iliac crest and fibula. Conclusion: The two graft bones could meet the needs of the various types of mandibular defects, but it must have an option for the different site and range of mandibular defect and soft tissue defect between iliac crest flap and fibular flap. For defect whose length was less than 8cm, priority can give to iliac bone, but for defect greater than 8cm fibula flap should choose.

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