Abstract: Objective: To evaluate the influence on the osseointegration of delayed implantation of dental implant with Bio-Oss artificial bone following tooth extraction. Methods: The bilateral 3rd and 4th mandibular premolars of 6 adult, healthy, male and female dogs were extracted. We randomly selected 2 extraction sockets in each dog to be filled with Bio-Oss (the experimental group); the other 2 extraction sockets which were not treated served as the control group. Dental implants were inserted into the alveolar bone of the experimental group and the control group 3 months after Bio-Oss placement. The osteogenic activity in the bone around the implants was assessed by evaluating the histological morphology and estimating histomorphometric parameters 3 and 6 months after delayed implantation. Results: After the 3 months, Goldner's trichrome staining analysis showed that the bone-implant contact rate and mineralized bone area around the implant were significantly higher in the experimental group (75.98%±8.97% and 69.52%±9.63%, respectively) than those in the control group (56.13%±8.18% and 52.82%±7.25%, respectively, P<0.05). However, no significant difference was found between the 2 groups after 6 months. Conclusion: These data indicate that alveolar ridge preservation by using Bio-Oss placement can promote osseointegration of delayed implantation, and may be a promising option for clinical use.

Key words: Bio-Oss Implant, Delayed implantation, Osseointegration