Abstract: Objective: To investigate the design, manufacture and application of individual titanium alloy mandible implant based on three dimensional printing of titanium alloy. Methods: A patient with large mandible body, angle and ramus ameloblastomas was given a spiral CT scanning. Based on the CT scanning, the pathological changed mandible was reconstructed, and after which simulated resection, individual mandible implant design and optimization was carried out. When the design of the implant was finished, the data of the implant was input into the three dimensional printing machine and the individual mandible implant was manufactured. During the operation, when the pathological mandible was removed, the mandible implant was accurately assembled immediately. Results: The titanium alloy mandible implant designed and manufactured based on three dimensional printing was highly individual anatomic emulation, and highly inosculated with healthy mandible. The shape and the function were renewed ideally. Conclusion: Three dimensional printing of titanium alloy made the design, manufacture and clinical application of highly individual anatomic emulated mandible implant realism. Optimized design could made the titanium alloy mandible implant has realistic biomechanical capability, light weight and right precision.

Key words: Mandible defect, Three-dimensional printing , Titanium alloy, Mandible implant