Effect of Photodynamic Therapy on Patients with Type II Diabetes Mellitus and Chronic Periodontitis.

doi:10.13701/j.cnki.kqyxyj.2016.10.016

Abstract

Abstract: Objective: To explore the therapeutic effect of photodynamic therapy (PDT) on patients with type II diabetes mellitus and chronic periodontitis. Methods: Forty-eight patients with chronic periodontitis were randomly divided into PDT group (n=24) and control group (n=24) with and without PDT after supragingival scaling, and scaling and root planning (SRP). Levels of fasting blood glucose (FGP) and glycosylated hemoglobin (HbAle), and periodontal status were examined as well as matrix metalloproteinase-8 (MMP-8) and interleukin-1 (IL-1).Results: The total effective rate of PDT group was 91.67%, which was significantly higher than the control group (P<0.05). Three months after treatment, the level of HbAle in PDT group was significantly lower than that of one week after supragingival scaling without PDT and the control group (P<0.05). PD, AL, BI, and PLI were significantly decreased in the two groups after 6 weeks and 3 months after treatment. Compared with the control group, the PDT group was significantly decreased (P<0.05). The level of MMP-8 and IL-1 were significantly decreased in two groups after treatment (P<0.05), while the PDT group decreased more significantly (P<0.05).Conclusion: PDT can effectively improve periodontitis patients with type II diabetes, and reduce the level of inflammation reaction.

Key words: Chronic periodontitis, Type II diabetes mellitus, Photodynamic therapy, Inflammatory factors

CLC Number:

R781.4

HOU Jia, TAO Hong.. Effect of Photodynamic Therapy on Patients with Type II Diabetes Mellitus and Chronic Periodontitis.[J]. Journal of Oral Science Research, 2016, 32(10): 1067-1069.

References

[1] Said AM, Zaki RG, Mohamed TH, et al. Safety and efficacy of photodynamic therapy using BCECF-AM compared to mitomycin C in controlling post-operative fibrosis in a rabbit model of subscleral trabeculectomy[J]. Int J Ophthalmol,2016,9(3)∶348-56
[2] 李先忠.光动力疗法联合龈下刮治和根面平整治疗术治疗牙周炎的疗效观察[J].中国美容医学,2014,23(24)∶2093-2096
[3] Cowan T, Tripathy D, Oates T. CAT OF THE MONTH. Critically Appraised Topics. Photodynamic Therapy (PDT) as an Adjunct to Scaling and Root Planning does not improve Periodontal Conditions in Type II Diabetic Patients with Chronic Periodontitis[J]. Tex Dent J,2016,133(1)∶18
[4] Gualberto EC Jr, Theodoro LH1, Longo M, et al. Antimicrobial photodynamic therapy minimizes the deleterious effect of nicotine in female rats with inducedperiodontitis[J]. Lasers Med Sci,2016,31(1)∶83-94
[5] Sreedhar A, Sarkar I, Rajan P, et al. Comparative evaluation of the efficacy of curcumin gel with and without photo activation as an adjunct to scaling and root planing in the treatment of chronic periodontitis: A split mouth clinical and microbiological study[J]. J Nat Sci Biol Med,2015,6(1)∶S102-9
[6] 刘西茜,冯云.光动力疗法对慢性牙周炎治疗效果的Meta分析[J].中国医学物理学杂志,2012,29(4)∶3550-3553
[7] Chatzopoulos GS, Doufexi AE. Photodynamic therapy in the treatment of aggressive periodontitis: A systematic review[J]. Med Oral Patol Oral Cir Bucal,2016,21(2)∶e192-200
[8] Oruba Z, Labuz P, Macyk W, et al. Antimicrobial photodynamic therapy-A discovery originating from the pre-antibiotic era in a novel periodontaltherapy[J]. Photodiagnosis Photodyn Ther,2015,12(4)∶612-618
[9] Souza E, Medeiros AC, Gurgel BC, et al. Antimicrobial photodynamic therapy in the treatment of aggressive periodontitis: a systematic review and meta-analysis[J]. Lasers Med Sci, 2016, 31(1)∶187-96

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