Expression and Significance of Pinx1 in Oral Squamous Cell Carcinoma.

doi:10.13701/j.cnki.kqyxyj.2016.10.015

Abstract

Abstract: Objective: To explore the expression and significance of Pinx1 in oral squamous cell carcinoma (OSCC). Methods: The expression of Pinx1 in 60 cases of OSCC and 20 cases of normal oral mucosa (NOM) was detected by immunohistochemistry. Results: The high expression of Pinx1 in the NOM epithelium was detected, and the positive rate was 100%. By contrast, the expression and positive rate (65%) of Pinx1 was significantly decreased in OSCC (P<0.05). With the increase of malignant degree, PinX1 expression showed a decreased trend (P<0.05). In addition, PinX1 expression level was significantly lower in OSCC patients with lymph node metastasis than those without lymph node metastasis (P<0.05). The expression of Pinx1 was not correlated with the gender and age of OSCC patients.Conclusion: Pinx1 may be related to the occurrence, development and metastasis of OSCC.

Key words: Pinx1, Oral squamous cell carcinoma, Immunohistochemistry

CLC Number:

R739.8

LV Shan-shan, WEI Xiu-feng, SUN Xin, ZHOU Yang, WEI Yu-xue, LIU Tong, GAO Xu.. Expression and Significance of Pinx1 in Oral Squamous Cell Carcinoma.[J]. Journal of Oral Science Research, 2016, 32(10): 1064-1066.

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