Expression of LncRNA FAL1 in Oral Squamous Cell Carcinoma and Its Relationship with Prognosis

doi:10.13701/j.cnki.kqyxyj.2019.04.013

Abstract

Abstract: Objective: To investigate the expression of long-chain non-coding RNA (LncRNA) FAL1 in oral squamous cell carcinoma (OSCC) and its relationship with prognosis. Methods: Ninty-five patients with OSCC admitted to Haikou People's Hospital and Xiangya No.2 Hospital of Central South University from January 2013 to May 2015 were enrolled in this study. The OSCC tissues surgically resected were set as OSCC group, and oral mucosal tissues of 50 healthy people were set as control group. Real time quantitative PCR was used to detect the expression level of LncRNA FAL1 in the two groups. The clinicopathological data of patients were collected. According to the median value of LncRNA FAL1 expression, OSCC group was divided into low expression group and high expression group. The relationship between the expression of LncRNA FAL1 and clinicopathological characteristics was analyzed. Kaplan-Meier method was used for survival analysis. Log-Rank method was used to examine the effect of LncRNA FAL1 expression on prognosis. Cox was used to analyze the related factors affecting OSCC. Results: The expression of LncRNA FAL1 in OSCC group was significantly higher than that in control group (P<0.05). LncRNA FAL1 was significantly correlated with clinical stage, T stage, differentiation degree, and lymphatic metastasis (P<0.05). Kaplan-Meier survival analysis showed that PFS and OS in LncRNA FAL1 low expression group were significantly higher than those in LncRNA FAL1 high expression group (P<0.05). Cox analysis showed that clinical stage, T stage, degree of differentiation, and lymphatic metastasis were all risk factors for OSCC. Conclusion: LncRNA FAL1 is highly expressed in tissues of patients with OSCC, and it may be closely related to the occurrence, development, and prognosis of OSCC.

Key words: Oral squamous cell carcinoma, Long-chain non-coding RNA FAL1, Clinical significance, Prognosi

BAI Zhen-yu, WANG Kai, LIU De-yu, HUANG Xie-shan. Expression of LncRNA FAL1 in Oral Squamous Cell Carcinoma and Its Relationship with Prognosis[J]. Journal of Oral Science Research, 2019, 35(4): 360-363.

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