Expression and Significance of Eya4 in Oral Squamous Cell Carcinoma

doi:10.13701/j.cnki.kqyxyj.2019.06.011

Abstract

Abstract: Objective: To study the expression and significance of eya4 protein in oral squamous cell carcinoma (OSCC). Methods: The expression of eya4 in oral mucosa of 60 patients with OSCC and 20 controls with normal oral mucosa (NOM) were detected by immunohistochemical staining. Results: Statistical analysis showed that eya4 was highly expressed in NOM tissues and highly differentiated OSCC squamous cell carcinoma tissues, with expression rates of 100% and 95%, respectively, while expression rate was only 5% in poorly differentiated OSCC squamous cell carcinoma tissues. This indicated that eya4 might be involved in the development of OSCC disease. In addition, by studying the relationship between the expression of eya4 and various clinicopathological parameters, the expression was not related to the age and sex of the patient. However, the eya4 expression levels were significantly lower in patients with lymph node metastasis than in patients without lymph node metastasis. Conclusion: Eya4 may influence the occurrence, development, and metastasis of OSCC.

Key words: EYA4, Oral squamous cell carcinoma, Immunohistochemistry

GAO Xu, ZHOU Yang, LI Chen, XUE Xiao-han, WEI Xiu-feng. Expression and Significance of Eya4 in Oral Squamous Cell Carcinoma[J]. Journal of Oral Science Research, 2019, 35(6): 555-558.

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