Significance of TGF-β1 Expression and Clinicopathological Characteristics on Prognosis for Oral Squamous Cell Carcinoma Patients.

doi:10.13701/j.cnki.kqyxyj.2019.05.006

Abstract

Abstract: Objective: To investigate transforming growth factor beta1 (TGF-β1) expression at tumor center and invasive tumor front and the prognostic value in oral squamous cell carcinoma (OSCC). Methods: Paraffin-embedded sections of 104 patients with primary OSCC were collected at Nanjing Stomatological Hospital. The sections were stained by immunohistochemistry (IHC) and focused on regions at tumor center (TC) and invasive tumor front (ITF). Results: Positive expression rates of TGF-β1 between TC and ITF were comparable (P>0.05). Moreover, TGF-β1 expression at TC and ITF positively associated with TNM stages, DOI, nerve invasion and recurrence (P<0.05). Kaplan-Meier analysis showed that high expression of TGF-β1 no matter at TC or ITF was significantly correlated with lower overall survival, recurrence-free survival, and disease-free survival (P<0.05). Notably, Cox multivariate analysis indicated that high expression of TGF-β1 at TC correlated to low overall survival in OSCC patients. Conclusion: TGF-β1 at TC could be an independent prognostic factor for overall survival in OSCC patients.

Key words: Oral squamous cell carcinoma, TGF-β1, Prognosis

LU Zhan-yi, HU Qin-gang, CHEN Sheng, YANG Yan, DING Liang, NI Yan-hong. Significance of TGF-β1 Expression and Clinicopathological Characteristics on Prognosis for Oral Squamous Cell Carcinoma Patients.[J]. Journal of Oral Science Research, 2019, 35(5): 433-438.

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