Expression and Clinical Significance of SOX-9 in Human Oral Squamous Cell Carcinoma.

doi:10.13701/j.cnki.kqyxyj.2019.05.007

Abstract

Abstract: Objective: To investigate the expression and clinical significance of SOX-9 in oral squamous cell carcinoma (OSCC). Methods: The expression of SOX-9 protein in normal oral mucosa, atypical hyperplasia of oral epithelium, and oral squamous cell carcinoma was detected by immunohistochemistry, and the correlation between SOX-9 protein and clinicopathological factors was analyzed. Results: The positive expression rates of SOX-9 in normal oral mucosa, atypical epithelial hyperplasia, and oral squamous cell carcinoma were 10% (2/20), 32.1% (9/28), and 79.4% (27/34), respectively. SOX-9 increased in three tissues in turn. The expression of SOX-9 increased in the process of tumor development, and the difference of expression in each group was statistically significant (P<0.001). The expression of SOX-9 was related to tumor volume, lymph node metastasis, and tumor stage. Single factor analysis showed that tumor volume, lymph node metastasis , tumor staging, and SOX-9 positive expression were related to survival time (P<0.05). After Cox multivariate analysis, only lymph node metastasis, tumor stage, and SOX-9 positive expression were independent factors affecting survival time (P<0.05). Conclusions: SOX-9 is highly expressed in oral squamous cell carcinoma. SOX-9 expression is associated with survival rate in patients with oral squamous cell carcinoma.

Key words: SOX-9, Oral squamous cell carcinoma, Atypical hyperplasia of oral mucosa

LIU Yan-ling, ZHAO Xi, YU Li, NIE Min-hai. Expression and Clinical Significance of SOX-9 in Human Oral Squamous Cell Carcinoma.[J]. Journal of Oral Science Research, 2019, 35(5): 439-442.

References

[1] 邬利波,潘淑婷,邱嘉旋.口腔鳞癌新辅助化疗前后多药耐药相关蛋白的表达及临床疗效分析[J].口腔医学研究,2017,33(12):1298-1301.
[2] 曾光,卫克文.MAP4K3-mTOR信号在甘草查而酮A诱导的鳞癌细胞自噬与凋亡中的作用研究[J].口腔医学研究,2017,33(12):1241-1245.
[3] Sono T, Akiyama H, Miura S, et al. THRAP3 interacts with and inhibits the transcriptional activity of SOX9 during chondrogeneses [J]. J Bone Miner Metab,2018,36(4):1-10.
[4] Sono T, Akiyama H, Miura S, et al. THRAP3 interacts with and inhibits the transcriptional activity of SOX-9 during chondrogenesis [J]. J Bone Miner Metab, 2017,36(4):410-419.
[5] Zhu Z, Dai J, Liao Y, et al. Sox9 protects against human lung fibroblast cell apoptosis induced by LPS through activation of the AKT/GSK3β pathway [J]. Biochemistry (Mosc), 2017,82(5):606-612.
[6] 潘静,许艳茹,沈娟娟.Lgr5及SOX-9在宫颈癌组织中的表达及其与预后的关系[J].临床和实验医学杂志, 2017, 16(15):1492-1495.
[7] Bremmer F, Behnes CL, Schildhaus HU, et al. The role of beta-catenin mutation and SOX-9 expression in sex cord-stromal tumours of the testis [J]. Virchows Arch, 2017,470(4):421-428.
[8] Lü B, Fang Y, Xu J, et al. Analysis of SOX-9 expression in colorectal cancer [J]. Am J Clin Pathol, 2008,130(6):897-904.
[9] 卓姗姗,张文超,潘毅,等.口腔鳞癌肿瘤巨细胞与临床病理因素的相关性研究[J].中国肿瘤临床, 2016,43(20):907-912.
[10] 邬利波,潘淑婷,邱嘉旋.口腔鳞癌新辅助化疗前后多药耐药相关蛋白的表达及临床疗效分析[J].口腔医学研究,2017,33(12):1298-1301.
[11] Huang CZ, Xu JH, Zhong W, et al. SOX-9 transcriptionally regulates Wnt signaling in intestinal epithelial stem cells in hypomethylated crypts in the diabetic state [J]. Stem Cell Res Ther, 2017,8(1):60-66.
[12] Huang J, Guo L. Knockdown of SOX-9 inhibits the proliferation, invasion, and EMT in thyroid cancer cells [J]. Oncol Res, 2017, 25(2):167-176.
[13] Santos JC, Carrasco-Garcia E, Garcia-Puga M, et al. SOX-9 elevation acts with canonical WNT signaling to drive gastric cancer progression [J]. Cancer Res,2016 ,76(22):6735-6746.
[14] Selvaraj P, Xiao L, Lee C, et al. Neurotrophic factor-α1: a key Wnt-β-Catenin dependent anti-proliferation factor and ERK-SOX-9 activated inducer of embryonic neural stem cell differentiation to astrocytes in neurodevelopment [J]. Stem Cells, 2017, 35(3):557-571.

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