Correlation between Shh Protein and Inflammatory Degree of Chronic Periodontitis

doi:10.13701/j.cnki.kqyxyj.2020.02.010

Abstract

Abstract: Objective: To investigate the correlation between Sonic Hedgehog (Shh) protein and inflammatory degree of chronic periodontitis in Shh signaling pathway. Methods: The gingival crevicular fluid samples were collected from 20 healthy controls, 20 patients with mild periodontitis, and 20 patients with moderate to severe periodontitis. Gingival crevicular fluid level of Shh protein, IL-6, and IL-10 were measured by enzyme linked immunosorbent assay (ELISA). Results: The levels of Shh protein and IL-6 in gingival crevicular fluid were higher in chronic periodontitis group than those in healthy control group (P<0.05), and in moderate and severe chronic periodontitis group were higher than those in mild chronic periodontitis group (P<0.05). The level of IL-10 in mild chronic periodontitis group was higher than that in healthy control group and moderate-severe chronic periodontitis group (P<0.05), and that in healthy control group was higher than that in moderate-severe chronic periodontitis group (P<0.05). The levels of Shh protein and IL-6 were positively correlated with BI and PD (P<0.05). Conclusion: Ssh signaling pathway may be involved in the inflammatory response of chronic periodontitis.

Key words: chronic periodontitis, gingival crevicular fluid, Shh protein, IL-6, IL-10

YANG Lei, GUO Liuyun, CHENG Zhifen, LI Bihao. Correlation between Shh Protein and Inflammatory Degree of Chronic Periodontitis[J]. Journal of Oral Science Research, 2020, 36(2): 131-134.

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