Evaluation on Efficacy of Thermosensitive Minocycline and Omidazole Complex Gel in Treatment of Chronic Periodontitis

doi:10.13701/j.cnki.kqyxyj.2019.07.008

Abstract

Abstract: Objective: To evaluate the clinical effect of thermosensitive minocycline and omidazole complex gel on chronic periodontitis. Methods: A total of 132 patients with chronic periodontitis were recruited in this prospective study and were randomly divided into observation group (n=66) and control group (n=66). Patients in control group were given minocycline ointment and patients in observation group were given thermosensitive minocycline and omidazole complex gel. The therapeutic effect, changes of periodontitis index, inflammatory factor level, and adverse reaction in two groups were compared. Results: The total effective rates were 95.45% and 83.33% in observation and control groups, respectively; the changes of periodontitis index, inflammatory factor level, and adverse reaction in the observation group were lower than those in the control group (P＜0.05). Conclusion: The local application of thermosensitive minocycline and omidazole complex gel can effectively improve the clinical symptoms of patients with chronic periodontitis.

Key words: chronic periodontitis, minocycline, omidazole , efficacy evaluation

WANG Li, YANG Xiaoyan. Evaluation on Efficacy of Thermosensitive Minocycline and Omidazole Complex Gel in Treatment of Chronic Periodontitis[J]. Journal of Oral Science Research, 2019, 35(7): 647-650.

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