Effect of Minocycline Hydrochloride Ointment on Subgingival Porphyromonas Gingivalis of Peri-microscrew Implantitis.

doi:10.13701/j.cnki.kqyxyj.2016.04.019

Abstract

Abstract: Objective: To investigate the effect of minocycline hydrochloride ointment on subgingival porphyromonas gingivalis of peri-microscrew implantitis. Methods: Fifteen patients (20 microscrews) with peri-microscrew implantitis from Jan 2013 to Jan 2015 were set as experimetal group and 14 patients (20 microscrews) without peri-microscrew implantitis were set as control group. Plaque index (PLI), probing pocket index (PD) and sulcus bleeding index (SBI) of all patitents were recorded. Real-time PCR was used to detect the Porphyromonas gingivalis. Results: The values of PLI, PD and SBI in experimental group were significantly higher than those in the control group (P<0.05). After treatment for 1 and 3 weeks, the values of PLI, PD and SBI in experimental group were significantly decreased (P<0.05). Before and after treatment for 6 weeks, the Pg relevance ratio in experimental group was significantly higher than that in control group (P<0.05). After treatment for 1 and 3 weeks, the relevance ratio in experimental group significantly decreased. There was significant positive Pearson correlation between the detection rate of Pg and the PLI, PD and SBI (P<0.05). Conclusion: Minocycline hydrochloride ointment treatment could improve clinical symptom and had inhibitory effect on subgingival porphyromonas gingivalis of peri-microscrew implantitis

CLC Number:

R783.5

SUN Fu-cai, YU Fang-you, LI Xian. Effect of Minocycline Hydrochloride Ointment on Subgingival Porphyromonas Gingivalis of Peri-microscrew Implantitis.[J]. Journal of Oral Science Research, 2016, 32(4): 395-398.

References

[1] 徐欣.种植修复在牙周病治疗中的应用[J].中国口腔种植学杂志,2011,16(1)∶12-13
[2] 蔡同道.盐酸米诺环素软膏治疗种植体周围炎的疗效观察[J].中国医学科学,2012,2(11)∶168-170
[3] 李嵘,沈国荣,王国荣.微螺钉种植体支抗的口腔正畸效果分析[J].中国临床医学,2014, 21(2)∶221-222
[4] William SP, Travess H, Sandy J. The use of osseointegrate in plants in orthodontic patients: in plant and their use in children [J]. Dent Update, 2013, 31(5)∶1287-1290
[5] Lehmann KM, Kammerer PW, Karbach J, et a1. Long-term effect of over denture bar design on per-implant tissues [J]. Int J Oral Maxillofac Implants, 2013, 28 (4)∶1126-1131
[6] 付文,张伟,易小英.盐酸米诺环素与碘合剂治疗种植体周围炎的临床疗效及安全性[J].实用药物与临床,2014,17(4)∶509-512
[7] Komiya Ito A, Ishihara K, Tomita S, et al. Investigation of subgingival profile of periodontopathic bacteria using polymerase chain reaction [J]. Bull Tokyo Dent Coll, 2010, 51(3)∶139-44
[8] 徐晓静.微螺钉种植体支抗在口腔正畸中的临床应用探讨[J].中国现代药物应用,2014,8(17)∶43-44
[9] 牛勇梅,秦晓中,杨玮,等.盐酸米诺四环素软膏对种植体周围炎的影响[J].中国药物与临床,2011,11(9)∶1069-1070
[10] 沈玉芹,鲍士金.盐酸米诺环素软膏辅助治疗慢性牙周炎疗效分析[J].中国医药,2012,7(2):∶221-222
[11] 邓淑丽,王颖,何佳燕,等.实时荧光定量PCR法检测治疗后敞下菌斑中优势菌的变化[J].上海口腔医学,2013,22(3)∶297-301
[12] Mxedx H, Fujimoto C, Hxruki Y, et al. Quantitative real-time PCR using TaqMan and SYBR Green for actinomycemcmito actinomycetemcomitans, Porphyroraonas gingivalis, vote tetQ gene and total bacteria [J]. FEMS Immunol Med Microbial, 2003, 39(1)∶81-86

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