Expression of Polycystin-1 in Cranial Base Spheno-occipital Synchondrosis of Growing Mouse.

doi:10.13701/j.cnki.kqyxyj.2017.08.006

Abstract

Abstract: Objective: To investigate the tempro-spatial characters of polycystin-1 (PC1) expression in mouse spheno-occipital synchondrosis (SOS) at different growth stages. Methods: Tissue sections of SOS of 1, 4,8 weeks postnatal mouse were prepared, then the expression of PC1 was detected with immunohistochemical staining and the percentage of positive area to synchondrosis area was calculated. Results: At the age of 1 week, the expression of PC1 in SOS was observed in reserve zone, pre-hypertrophy zone, and early hypertrophy zone; at 4 weeks, PC1 expression in reserve zone, proliferation zone, and pre-hypertrophy zone was obviously enhanced; at 8 weeks, the PC1 expression was concentrated in pre-hypertrophy zone and hypertrophy zone. The mean percentages of positive area were 4.51%, 5.7% and 4.59% at 1week, 4 weeks and 8 weeks, respectively. The difference between 4-week-old group and any other group was significant (P<0.05). Conclusion: PC1 is expressed in spheno-occipital synchondrosis of growing mouse, but its site and level vary at different growth stages.

Key words: Polycystin-1 , Mouse Cranial base, Spheno-occipital synchondrosis

CLC Number:

R783.5

GAO Guo-jie,ZHANG Xiao-yue,SHEN Gang.. Expression of Polycystin-1 in Cranial Base Spheno-occipital Synchondrosis of Growing Mouse.[J]. Journal of Oral Science Research, 2017, 33(8): 824-827.

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