Abstract: Objective: To establish experimental periodontitis model in rats, the detection of CRP (C reaction protein), ICAM-1 (intercellular adhesion molecule -1), E-selectin expression in rat periodontal tissues and level of rat serum, to investigate the changes of CRP, ICAM-1, E-selectins in the development of periodontitis. Methods: Pure 6-month-old 40 male SD rats were randomly divided into 4 groups, the normal group (group A), the 4 weeks periodontitis group (group B), the 8 weeks periodontitis group (group C), the 12 weeks periodontitis group (group D), 10 rats in each group. Establishment of experimental animal model of periodontitis, according to kill the experimental rats, were used to detect the changes of CRP, ICAM-1, E-selectins of periodontal tissue and serum. Results: The experimental periodontitis with the extension of time, periodontal destruction degree deepening, CRP, ICAM-1, E-selectins of periodontal tissue and serum increased continuously, periodontal tissue inflammation may further aggravate. Conclusion: CRP, ICAM-1, E-selectins as the joint dangerous cytokine periodontitis and cardiovascular and cerebrovascular diseases, not only changes with the increase of periodontal inflammation, but also as periodontitis risk factors of cardiovascular and cerebrovascular disease evidence.

Key words: Experimental periodontitis, C reactive protein , Intercellular adhesion molecule -1, E-selectins