Effect of Early Life Stress on the Progression of Experimental Periodontitis in Rats.

doi:10.13701/j.cnki.kqyxyj.2017.03.003

Abstract

Abstract: Objective: To explore the effect of early life stress on the progression of experimental periodontitis in rats. Methods: Twenty male SD rats of 3 weeks old were divided into two groups randomly. One group was suffered the unpredictable chronic mild stress (UCMS) procedure and the other was the control group. After five weeks' UCMS procedure, all rats received the operation of experimental periodontitis (EP). Then the behavioral tests, sucrose preference test, serum corticosterone (CORT) and inflammatory cytokines by ELISA, and HE staining were performed. Results: The UCMS rats showed the depression-like behaviors, including enhanced immobility time in forced swimming test (P<0.01) and lower sucrose preference test (P<0.001). Serum corticosterone, IL-1β and TNF-α was also elevated (P<0.05). In HE staining, rats with EP showed an obvious alveolar bone loss compared with that in the contra-lateral left side. The alveolar bone loss in the UCMS rats was significantly more severe compared with control group (P<0.001). The same tendency was found in the osteoclast numbers (P<0.001). Positive correlation was found between serum corticosterone and severity of EP (P<0.05). Conclusion: Early life stress could aggravate the progression of EP, which might be regulated by HPA axis and humoral immunity.

Key words: Early life, Stress, Experimental periodontitis, Rats

CLC Number:

R781.4

LIU Fei, ZHANG Lin, XIAO Gang, GUO Qing-yu.. Effect of Early Life Stress on the Progression of Experimental Periodontitis in Rats.[J]. Journal of Oral Science Research, 2017, 33(3): 244-248.

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