Effect of Stress State in Implant-bone Interface on Bone Osteocytes in Peri-implant Bone

doi:10.13701/j.cnki.kqyxyj.2019.10.007

Abstract

Abstract: Objective: To investigate the effect of stress state on bone osteocytes around dental implants using finite element analysis and animal experiment. Methods: The designed implants including full-thread and delete-thread implant were placed in proximal tibial metaphysis of rabbits. The animals were sacrificed at 7 days, 15 days, 30 days, and 60 days after surgery, and undecalcified tissue sections were prepared for SEM. The finite element models of implants and tibia metaphysis were installed and the process of implantation was simulated by computer-aided design software. The von Mises stress in peri-implant bone were recorded and analyzed. Results: The surrounding bone within 0.75 mm from surface of implant in full-thread implant group exhibited higher von Mises stress than delete-thread implant. The SEM images indicated that the number and morphological of osteocytes between two groups of implants at 7 days and 14 days were significantly different. Conclusion: The FEA can simulate the stress distribution on peri-implant bone in the initial state after implantation. The biological activity of osteocyte may be closely related to the stress state, which demonstrated a better response to stress stimuli in early stage of osseointegration and changes of number and morphology of osteocyte.

Key words: finite element analysis, stress, osteocyte

JIN Zhiheng, LI Qing. Effect of Stress State in Implant-bone Interface on Bone Osteocytes in Peri-implant Bone[J]. Journal of Oral Science Research, 2019, 35(10): 936-939.

References

[1] Liang K, Zhao Y, Hu K, et al. Selection of the implant thread pitch for optimal biomechanical properties: A three-dimensional finite element analysis [J]. Adv Eng Softw, 2009, 40(7):474-478.
[2] Piattelli A, Artese L, Penitente E, et al. Osteocyte density in the peri-implant bone of implants retrieved after different time periods (4 weeks to 27 years) [J]. J Biomed Mater Res Part B, 2014, 102(2):239-243.
[3] Barros RR, Degidi M, Novaes AB, et al. Osteocyte density in the peri-implant bone of immediately loaded and submerged dental implants [J]. J Periodont, 2009, 80(3):499-504.
[4] Kuroshima S, Yasutake M, Tsuiki K, et al. Structural and qualitative bone remodeling around repetitive loaded implants in rabbits [J]. Clin Implant Dent Relat Res, 2015, 17 Suppl 2:e699-e710.
[5] Hudieb MI, Wakabayashi N, Kasugai S. Magnitude and direction of mechanical stress at the osseointegrated interface of the microthread implant [J]. J Periodontol, 2011, 82(7):1061-1070.
[6] Wolff J, Narra N, Antalainen AK, et al. Finite element analysis of bone loss around failing implants [J]. Mater Des, 2014, 61:177-184.
[7] Feng JQ, Ward LM, Liu S, et al. Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism [J]. Nature Genet, 2006, 38(11):1310-1315.
[8] 高雪,张栋梁.三维有限元法在舌侧正畸领域的应用[J].口腔医学研究, 2017, 33(3):342-344.
[9] Chang HS, Chen YC, Hsieh YD, et al. Stress distribution of two commercial dental implant systems: A three-dimensional finite element analysis [J]. J Dental Sci, 2013, 8(3):261-271.
[10] Slotte C, Lundgren D, Sennerby L, et al. Surgical intervention in enchondral and membranous bone: intraindividual comparisons in the rabbit [J]. Clin Implan Dent Relat Res, 2003, 5(4):263-268.
[11] Sasaki M, Kuroshima S, Aoki Y, et al. Ultrastructural alterations of osteocyte morphology via loaded implants in rabbit tibiae [J]. J Biomech, 2015, 48(15):4130-4141.
[12] Kuroshima S, Nakano T, Ishimoto T, et al. Optimally oriented grooves on dental implants improve bone quality around implants under repetitive mechanical loading [J]. Acta Biomater, 2017, 48:433-444.
[13] Hou PJ, Ou KL, Wang CC, et al. Hybrid micro/nanostructural surface offering improved stress distribution and enhanced osseointegration properties of the biomedical titanium implant [J]. J Mech Behav Biomed Mater, 2018, 79:173-180.
[14] Boskey AL, Coleman R. Aging and bone [J]. J Dent Res, 2010, 89(12):1333.
[15] Bellido T. Osteocyte-driven bone remodeling [J]. Calcif Tissue Int, 2014, 94(1):25-34.
[16] Kleinnulend J, Bacabac RG, Bakker AD. Mechanical loading and how it affects bone cells: the role of the osteocyte cytoskeleton in maintaining our skeleton [J]. Eur Cells Mater, 2012, 24(7):278-291.
[17] Milovanovic P, Zimmermann EA, Hahn M, et al. Osteocytic canalicular networks: morphological implications for altered mechanosensitivity [J]. ACS Nano, 2013, 7(9):7542-7551.
[18] Prendergast PJ, Huiskes R, Soballe K. Biophysical stimuli on cells during tissue differentiation at implant interfaces [J]. J Biomech, 1997, 30(30):539-548.
[19] Tatsumi S, Ishii K, Amizuka N, et al. Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction [J]. Cell Metab, 2007, 5(6):464-475.