Abstract: Objective: To prove the safety and promotion effect of hyperbaric oxygenation treatment in oral submucous fibroisis patients with local injection with Danshen and triamcinolone acetonide. Methods: 46 patients were assigned into three groups randomly in the clinical trial. The patients in group A accepted hyperbaric oxygenation treatment twice a week for 8 weeks. The patients in group B accepted local injection with Danshen and triamcinolone acetonide for 8 weeks. The patients in group C accepted both treatment for 8 weeks. Results: The patients in three groups presented different curing effect without obvious side effect. At 8 weeks, the maximum mouth opening was (2.94±1.01)mm, (3.89±0.67)mm, and (6.14±1.46)mm in group A, B, and C, respectively. At 12 weeks after the finish of treatment, the maximum mouth opening was (2.94±1.01)mm and (1.98±0.78)mm, (3.18±0.66)mm and (5.42±1.53)mm in group A, B, and C, respectively. The amelioration degree of mouth sense was (1.15±0.31), (2.08±0.60), and (2.80±0.78) in group A, B, and C at 8 weeks, respectively. At 12 weeks after the finish of treatment, the amelioration degree of mouth sense was (2.00±0.72), (3.08±0.73), (3.38±0.94) in group A, B, and C at 8 weeks, respectively. Conclusion: Hyperbaric oxygenation treatment could promote the curing effect of local injection with danshen and triamcinolone acetonide with good rate and safety.

Key words: Hyperbaric oxygenation , Danshen , Triamcinolone acetonide , Oral submucous fibrosis