Vitamin C Enhanced the Expressions of Histone Demethylase KDM2B and KDM5C in Stem Cells from Apical Papilla.

Abstract

Abstract: Objective: To investigate whether Vitamin C could regulate the expression of histone demethylases in stem cells from apical papilla (SCAPs). Methods: Different doses of Vitamin C were used to stimulate the SCAPs. The qRT-PCR was used to detect the expression of histone demethylases at the mRNA level. Results: The qRT-PCR results showed that the expressions of KDM2B and KDM5C were up-regulated at 2, 4 and 8h after 10 μmol/L Vitamin C treatment in a time dependent manner. And 5, 10 and 20 μmol/L Vitamin C could increase the expressions of KDM2B and KDM5C in a dose dependent manner at 8h. Conclusion: Vitamin C could induce the expressions of histone demethylase KDM2B and KDM5C in SCAPs.

Key words: Vitamin C , Histone demethylase, SCAPs, KDM2B , KDM5C

CLC Number:

R780.1

WANG Yue-jun, LIU Da-yong, FAN Zhi-peng, et al.. Vitamin C Enhanced the Expressions of Histone Demethylase KDM2B and KDM5C in Stem Cells from Apical Papilla.[J]. Journal of Oral Science Research, 2015, 31(5): 466-469.

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