Abstract: Objective: To evaluate the diagnosis, treatment and prognosis of aggressive fibromatosis in head and neck region. Methods: Patients with aggressive fibromatosis in head and neck region from 2001 to 2014 were treated by operation and retrospectively studied in our department. Results: According to the diagnostic criteria of WHO in 2005, 9 cases of patients with aggressive fibromatosis occurred in head and neck region. So far, 3 cases relapsed. Conclusion: The head and neck structures were complex and operation space was limited. The recommended safe margin was 0.5~1 cm. For patients with complete resection, the prognosis was satisfactory, but tumor recurrence might still exist. If the lesions were adjacent to the important anatomic structure, partial resection combined with postoperative radiotherapy was suggested, and the long-term curative effect needed to be further investigated.

Key words: Aggressive fibromatosis, Extended resection, Radiotherapy