口腔鳞癌患者血清膜联蛋白A2表达及其与放疗敏感性的关系

doi:10.13701/j.cnki.kqyxyj.2019.02.008

摘要/Abstract

摘要： 目的: 探讨口腔鳞癌患者血清膜联蛋白A2表达水平及其与放疗敏感性的关系。方法: 选择2015年～2018年在本院进行诊治的77例中晚期口腔鳞癌患者作为病例组,50例健康者作为对照组,病例组术前进行三维适形放射治疗,分别检测两组血清膜联蛋白A2水平,分析血清膜联蛋白A2在不同放疗敏感性患者中的差异,采用受试者工作特征曲线(ROC)分析放疗前血清膜联蛋白A2水平对口腔鳞癌患者放疗敏感性的预测价值。结果: 77例口腔鳞癌患者经放射治疗后,完全缓解29例,部分缓解41例,无效7例,放疗总有效率90.91％;病例组治疗前后血清膜联蛋白A2水平显著高于对照组(P＜0.05); 完全缓解组治疗前血清膜联蛋白A2水平显著低于部分缓解组和无效组(P＜0.05),部分缓解组治疗前血清膜联蛋白A2水平显著低于无效组(P＜0.05);完全缓解组和部分缓解组治疗后血清膜联蛋白A2水平显著降低(P＜0.05),无效组治疗后血清膜联蛋白A2水平与治疗前相比差异无统计学意义(P＞0.05);血清膜脂蛋白A2与口腔鳞癌患者肿瘤大小、淋巴结转移有关(P＜0.05);放疗前血清膜联蛋白A2预测口腔鳞癌患者放疗敏感性的ROC曲线下面积(AUC)为0.755,敏感性为71.40 ％,特异性为75.70％。结论: 血清膜联蛋白A2与口腔鳞癌患者术前放疗敏感性密切相关,可作为预测患者放疗敏感性的生物标志物,对口腔鳞癌临床治疗方案制定具有重要指导意义。

关键词: 口腔鳞癌, 膜联蛋白A2, 放疗敏感性, ROC曲线

Abstract: Objective : To investigate the expression level of serum annexin A2 in oral squamous cell carcinoma (OSCC) and its relationship with radiosensitivity. Methods: From 2015 to 2018, 77 cases of middle and advanced oral squamous cell carcinoma treated in our hospital were collected in the case group and 50 healthy persons were collected in the control group. Three-dimensional conformal radiation therapy before operation was applied in the case group. The level of serum annexin A2 was detected in the two groups, respectively. The difference of serum annexin A2 in patients with different radiosensitivity was analyzed. Receiver operating characteristic curve (ROC) was used to analyze the predictive value of serum annexin A2 level before radiotherapy in patients with oral squamous cell carcinoma. Results: In 77 cases of oral squamous cell carcinoma patients after the radiotherapy, 29 cases were completely relieved, 41 cases were partial remission, 7 cases were ineffective, and the total effective rate of radiotherapy was 90.91%. The serum annexin A2 level in case group before and after treatment was significantly higher than that in control group (P<0.05); the level of serum annexin A2 before treatment in the complete remission group was significantly lower than that in the partial remission group and the ineffective group (P<0.05); the serum annexin A2 level in the partial remission group was significantly lower than the ineffective group before the treatment (P<0.05); the serum annexin A2 level in the complete remission group and the partial remission group was significantly decreased (P<0.05); the serum annexin A2 level in the ineffective group was not statistically significant compared with that before treatment (P>0.05); serum membrane lipoprotein A2 was associated with tumor size and lymph node metastasis in oral squamous cell carcinoma (P<0.05); the area of ROC curve (AUC) was 0.755; the sensitivity was 71.40%; and the specificity was 75.70% for the prediction of radiosensitivity in patients with oral squamous cell carcinoma before radiotherapy. Conclusion: Serum annexin A2 is closely related to radiosensitivity in patients with oral squamous cell carcinoma, and can be used as a biomarker to predict the sensitivity of radiotherapy for patients. It has important guiding significance for the development of clinical treatment plan for oral squamous cell carcinoma.

Key words: Oral squamous cell carcinoma, Annexin A2, Radiosensitivity, ROC curve

王玉梅,刘炜炜,陈力. 口腔鳞癌患者血清膜联蛋白A2表达及其与放疗敏感性的关系[J]. 口腔医学研究, 2019, 35(2): 133-136.

WANG Yu-mei, LIU Wei-wei, CHEN Li. Expression of Serum Annexin A2 in Oral Squamous Cell Carcinoma and Its Relationship with Radiosensitivity.[J]. Journal of Oral Science Research, 2019, 35(2): 133-136.

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