2型群体感应自诱导分子对牙周炎影响的研究进展

doi:10.13701/j.cnki.kqyxyj.2023.07.003

摘要/Abstract

摘要： 口腔环境中,作为牙周组织炎症的始动因子——牙菌斑细菌,在牙周炎的发生发展过程中起到重要作用,群体感应信号分子是细菌之间进行信号传导从而有效地调节种群密度和促进生物膜发展的重要分子。不同种类细菌其群体感应系统不同,但2型自诱导分子系统是牙周致病菌通用群体感应系统。近年来,许多研究表明群体感应抑制剂可以有效减弱牙周致病菌群体感应并抑制菌斑生物膜的形成和毒力因子的表达。本文就2型自诱导分子对牙周炎影响的研究进展进行综述。

关键词: 2型自诱导分子, 群体感应抑制剂, 牙周炎

Abstract: In the oral environment, plaque bacteria, as the initiator of periodontal tissue inflammation, play an important role in the development of periodontitis. Quorum sensing signaling molecules are important molecules that could perform signal transduction between bacteria to effectively regulate population density and promote biofilm development. Different species of bacteria have different quorum-sensing systems, but autoinducer 2 system is the most important universal quorum-sensing system of periodontal pathogens. In recent years, many studies have shown that quorum sensing inhibitors can effectively attenuate quorum sensing between bacteria and inhibit and reduce the formation of plaque biofilms between periodontal pathogens and the expression of their virulence factors. In this paper, the research progress in the effects of autoinducer 2 quorum sensing signaling molecules on periodontitis is reviewed.

Key words: autoinducer 2, quorum sensing inhibitors, periodontitis

王德续, 陈晓涛. 2型群体感应自诱导分子对牙周炎影响的研究进展[J]. 口腔医学研究, 2023, 39(7): 578-581.

WANG Dexu, CHEN Xiaotao. Research Progress in Effect of Autoinducer 2 on Periodontitis[J]. Journal of Oral Science Research, 2023, 39(7): 578-581.

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