儿童涎腺透明细胞变异型黏液表皮样癌1例

doi:10.13701/j.cnki.kqyxyj.2024.08.016

口腔医学研究 ›› 2024, Vol. 40 ›› Issue (8): 746-748.DOI: 10.13701/j.cnki.kqyxyj.2024.08.016

儿童涎腺透明细胞变异型黏液表皮样癌1例

潘越, 张玉杰, 张淑坤^*

山东省医药卫生老年消化道肿瘤病理重点实验室,山东大学附属威海市立医院病理科山东威海 264299

收稿日期:2023-11-22 出版日期:2024-08-28 发布日期:2024-08-22
通讯作者: *张淑坤,E-mali: zhangshukun0475@126.com
作者简介:潘越(1996~ ),男,山东威海人,硕士,医师,研究方向:肿瘤,临床病理学。

Clear Cell Variant of Mucoepidermoid Carcinoma of Salivary Gland in Children: A Case Report

PAN Yue, ZHANG Yujie, ZHANG Shukun^*

Shandong Probincial Key Medical and Health Laboratory of Weihai Municipal Hospital; Weihai Municipal Hospital, Cheeloo College of Medicine, Shandong University, Weihai 264299, China

Received:2023-11-22 Online:2024-08-28 Published:2024-08-22

摘要/Abstract

摘要： 黏液表皮样癌(mucoepidermoid carcinoma,MEC)是儿童与年轻人中最常见的涎腺来源的恶性肿瘤,男女比例约为3∶2。经典的MEC由黏液细胞、表皮样细胞及中间细胞按照不同比例组成,除经典的3种细胞成分外还存在一些少见亚型,其中透明细胞亚型是指肿瘤中透明细胞的比例超过其他3种经典型细胞成分的亚型。分子遗传学方面,多数MEC存在CRTC1/MAML2基因融合。本文报道1例发生于儿童腭部黏膜的透明细胞型中分化MEC。

关键词: 黏液表皮样癌, 透明细胞亚型, 临床病理, 鉴别诊断

Abstract: Mucoepidermoid carcinoma (MEC) is the most common malignant tumor of salivary gland origin in children and young adults, with a male-to-female ratio of approximately 3∶2. Classical MEC consists of mucous cells, epidermoid cells, and mesenchymal cells in various proportions, and there are some rare subtypes in addition to the classical three cellular components, among which, the clear-cell subtype is the one in which the percentage of clear cells in the tumor exceeds that of the other three classic cellular components. In terms of molecular genetics, most mucoepidermoid carcinomas have a CRTC1/MAML2 gene fusion. In this article, we report a case of clear cell type moderately differentiated mucoepidermoid carcinoma occurring in the palatal mucosa of a child, in order to improve the diagnostic ability of this type of disease in the future, and to reduce the occurrence of misdiagnosis and underdiagnosis.

Key words: mucoepidermoid carcinoma, clear cell subtype, clinicopathology, differential diagnosis

潘越, 张玉杰, 张淑坤. 儿童涎腺透明细胞变异型黏液表皮样癌1例[J]. 口腔医学研究, 2024, 40(8): 746-748.

PAN Yue, ZHANG Yujie, ZHANG Shukun. Clear Cell Variant of Mucoepidermoid Carcinoma of Salivary Gland in Children: A Case Report[J]. Journal of Oral Science Research, 2024, 40(8): 746-748.

参考文献

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儿童涎腺透明细胞变异型黏液表皮样癌1例

Clear Cell Variant of Mucoepidermoid Carcinoma of Salivary Gland in Children: A Case Report

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