表没食子儿茶素没食子酸酯抗龋机制的研究进展

doi:10.13701/j.cnki.kqyxyj.2025.04.002

摘要/Abstract

摘要： 龋病是一种常见的口腔疾病,临床表现为牙体硬组织慢性和进行性破坏。绿茶中的儿茶素已经被证明具有预防和控制龋病的作用,其中表没食子儿茶素没食子酸酯(epigallocatechin gallate, EGCG)是绿茶儿茶素中含量最丰富且有效的活性成分。EGCG具有抗致龋菌、抑制牙本质胶原降解、调整唾液膜蛋白含量及成分的功能。本文就EGCG控制龋病发生发展的上述3个作用机制的研究进展进行综述,以期为预防和治疗龋病提供新的用药策略。

关键词: 表没食子儿茶素没食子酸酯, 龋病, 致龋菌, 基质金属蛋白酶, 唾液蛋白

Abstract: Dental caries is a common oral disease with clinical manifestations of chronic and progressive destruction of dental hard tissues. Catechins in green tea have been shown to have caries-preventive and caries-control effects, with epigallocatechin gallate (EGCG) being the most abundant and potent active constituent of green tea catechins. EGCG has the functions of anti-cariogenic bacteria, inhibiting the degradation of dentin collagen, and adjusting the content and composition of salivary membrane proteins. This article reviews the research progress of the above three mechanisms of action of EGCG in controlling the occurrence and development of caries, in order to provide new drug strategies for the prevention and treatment of caries.

Key words: EGCG, dental caries, cariogenic bacteria, matrix metalloproteinase, salivary protein

叶慧翎, 王瑞. 表没食子儿茶素没食子酸酯抗龋机制的研究进展[J]. 口腔医学研究, 2025, 41(4): 276-281.

YE Huiling, WANG Rui. Research Progress on Anti-caries Mechanism of Epigallocatechin Gallate[J]. Journal of Oral Science Research, 2025, 41(4): 276-281.

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