功能性复合支架在骨组织工程中的研究进展

doi:10.13701/j.cnki.kqyxyj.2025.05.003

摘要/Abstract

摘要： 自体骨移植术作为临床上治疗大面积骨缺损的“金标准”,仍具有供体来源有限且易造成二次创伤等局限性。骨组织工程中功能性复合支架具有机械性能强、生物相容性高等特点,各种细胞生长因子、药物、金属离子等加入赋予支架促增殖、抗炎、成骨等生物学特性,由此形成的功能性复合支架为骨缺损治疗提供了新选择,有望成为自体骨材料的替代方案。本文就近年来骨组织工程中各种功能性复合支架的研究进展做一综述,为后续功能性复合支架的设计与应用提供参考及策略。

关键词: 骨组织工程, 骨缺损修复, 功能性复合支架

Abstract: Autologous bone grafting, as the clinical "gold standard" for the treatment of major bone defects, still has limitations including limited donor sites and the extra trauma. Functional composite scaffolds in bone tissue engineering are characterized by high mechanical strength and biocompatibility, etc. Various substances, such as cell growth factors, drugs, and metal ions, endow the scaffolds with biological features of proliferation promoting, anti-inflammation, and osteogenesis. The resulting functional composite scaffolds provide a new alternative for the treatment of bone defects, which is expected to replace autologous bone. This study summarizes the latest research of various functional composite scaffolds in bone tissue engineering in recent years, providing reference and strategy for the follow-up design and application of functional composite scaffolds.

Key words: bone tissue engineering, bone defect repair, functional composite scaffolds

牛德龙, 柳忠豪. 功能性复合支架在骨组织工程中的研究进展[J]. 口腔医学研究, 2025, 41(5): 373-377.

NIU Delong, LIU Zhonghao. Research Progress on Functional Composite Scaffolds in Bone Tissue Engineering[J]. Journal of Oral Science Research, 2025, 41(5): 373-377.

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