聚乳酸-羟基乙酸共聚物微球在骨组织工程中的应用

doi:10.13701/j.cnki.kqyxyj.2020.09.005

口腔医学研究 ›› 2020, Vol. 36 ›› Issue (9): 817-820.DOI: 10.13701/j.cnki.kqyxyj.2020.09.005

聚乳酸-羟基乙酸共聚物微球在骨组织工程中的应用

王健群, 张斌^*

哈尔滨医科大学附属第二医院硬组织工程实验室黑龙江哈尔滨 150001

收稿日期:2019-10-21 出版日期:2020-09-28 发布日期:2020-09-15
通讯作者: *张斌,E-mail: zhangbin@hrbmu.edu.cn
作者简介:王健群(1991~),男,黑龙江哈尔滨人,硕士在读,主要从事骨组织再生研究。
基金资助:
国家自然科学基金青年项目(编号:81500816)

Application of Poly(lactic-co-glycolic acid) Copolymer Microspheres in Bone Tissue Engineering

WANG Jianqun, ZHANG Bin^*

Institute of Hard Tissue Development and Regeneration, the Second Affiliated Hospital of Harbin Medical University, Harbin 150001, China

Received:2019-10-21 Online:2020-09-28 Published:2020-09-15

摘要/Abstract

摘要： 聚乳酸-羟基乙酸共聚物作为一种复合材料,具有生物相容性、低毒性以及作为载体能够包封及保护生物因子的能力。本文以聚乳酸-羟基乙酸共聚物的理化性质为基础,对聚乳酸-羟基乙酸共聚物微球的合成及其在骨组织工程中的应用进展作一综述,为该材料在骨组织工程中的应用提供借鉴。

关键词: 聚乳酸-羟基乙酸共聚物微球, 骨组织工程, 微球

Abstract: As a kind of composite material, Poly(lactic-co-glycolic acid) (PLGA) copolymer has biocompatibility, low toxicity, and the ability to encapsulate and protect biological factors. Based on the physical and chemical properties of PLGA, the synthesis of PLGA microspheres and its application in bone tissue engineering are reviewed in this paper, with hope to provide reference for the application of PLGA in bone tissue engineering.

Key words: poly(lactic-co-glycolic acid) copolymer nanoparticle, bone tissue engineering, nanoparticle

王健群, 张斌. 聚乳酸-羟基乙酸共聚物微球在骨组织工程中的应用[J]. 口腔医学研究, 2020, 36(9): 817-820.

WANG Jianqun, ZHANG Bin. Application of Poly(lactic-co-glycolic acid) Copolymer Microspheres in Bone Tissue Engineering[J]. Journal of Oral Science Research, 2020, 36(9): 817-820.

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聚乳酸-羟基乙酸共聚物微球在骨组织工程中的应用

Application of Poly(lactic-co-glycolic acid) Copolymer Microspheres in Bone Tissue Engineering

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